Detection of Residual Colorectal Liver Metastases Within 24 Hours After RFA With 18-F FDG PET
- Determine the sensitivity and specificity of fludeoxyglucose F 18 (FDG)-PET imaging in
detecting residual disease within 48 hours after radiofrequency ablation (RFA) of liver
metastases in patients with colorectal cancer.
- Determine the findings on day 7 after RFA using FDG-PET imaging in these patients.
OUTLINE: This is a prospective study.
Patients undergo fludeoxyglucose F 18 (FDG)-PET imaging at baseline. They then undergo
percutaneous laparoscopic or intraoperative radiofrequency ablation (RFA). Patients then
undergo further FDG-PET scans within 48 hours and 7 days after RFA. FDG-PET images are
evaluated for residual disease, including focal FDG uptake at the site of ablation.
Beginning 1 month after RFA, patients undergo contrast-enhanced MRI for routine
post-ablation follow-up. MRI scans are performed at 1, 4, 7, 12, 18, and 24 months after
completion of RFA.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Sensitivity and specificity of fludeoxyglucose F 18 (FDG)-PET imaging in early diagnosis of residual disease
Amir H. Khandani, MD
UNC Lineberger Comprehensive Cancer Center
United States: Federal Government
|Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill||Chapel Hill, North Carolina 27599-7570|