Quantitative Diffusion and Fat Imaging of Vertebral Fractures
Researchers believe that they may be able to use MRI scans to tell if fractures of the bones
in the spine are due to cancer. They believe this can be done by looking at MRIs of
diffusion (the random motion of molecules) and fat. For benign and malignant processes,
either diffusion or fat, or both of them, can be different, because the cell density (which
affects diffusion) and bone marrow content (which affects fat) are expected to be different.
All patients in this study will have already been scheduled for MRI exams of the spine at
You will have one extra MRI sequence done to look for relative fat, and a second extra MRI
sequence done to look for the diffusion. The extra time required for the study should be
less than 10 minutes, and the total imaging time should fall within a standard MRI time
Available data from your medical record, including imaging data, will be used to set up
guidelines and clear examples for checking spinal fractures.
This is an investigational study. A total of 48 patients will take part in the study. All
will be enrolled at UTMDACC.
Observational Model: Case-Only, Time Perspective: Prospective
MRIs of diffusion (the random motion of molecules) and fat
One extra 10 minute MRI sequence during scheduled spine exam.
Jingfei Ma, PhD
M.D. Anderson Cancer Center
United States: Institutional Review Board
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