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Quantitative Diffusion and Fat Imaging of Vertebral Fractures

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Trial Information

Quantitative Diffusion and Fat Imaging of Vertebral Fractures

Researchers believe that they may be able to use MRI scans to tell if fractures of the bones
in the spine are due to cancer. They believe this can be done by looking at MRIs of
diffusion (the random motion of molecules) and fat. For benign and malignant processes,
either diffusion or fat, or both of them, can be different, because the cell density (which
affects diffusion) and bone marrow content (which affects fat) are expected to be different.

All patients in this study will have already been scheduled for MRI exams of the spine at

You will have one extra MRI sequence done to look for relative fat, and a second extra MRI
sequence done to look for the diffusion. The extra time required for the study should be
less than 10 minutes, and the total imaging time should fall within a standard MRI time

Available data from your medical record, including imaging data, will be used to set up
guidelines and clear examples for checking spinal fractures.

This is an investigational study. A total of 48 patients will take part in the study. All
will be enrolled at UTMDACC.

Inclusion Criteria:

1. Patients with suspected vertebral compression fractures scheduled a standard of care
MRI of the spine.

Exclusion Criteria:

1. Patients who are contraindicated for MRI (such as due to metal implants, cardiac

2. Patients who are unable to give informed consent

3. Patients who are younger than 18 years of age since the disease (osteoporosis) is not
present in children.

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

MRIs of diffusion (the random motion of molecules) and fat

Outcome Time Frame:

One extra 10 minute MRI sequence during scheduled spine exam.

Safety Issue:


Principal Investigator

Jingfei Ma, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

M.D. Anderson Cancer Center


United States: Institutional Review Board

Study ID:




Start Date:

August 2004

Completion Date:

July 2009

Related Keywords:

  • Osteoporosis
  • Osteoporosis
  • Magnetic Resonance Imaging
  • Vertebral Fractures
  • Quantitative Diffusion
  • Fat Imaging
  • Spine
  • Osteoporosis
  • Spinal Fractures



U.T.M.D. Anderson Cancer CenterHouston, Texas  77030