Arginine Feeding: a Novel Strategy to Improve Protein Metabolism in Cancer and the Response to Surgery
In the present proposal, the effects of surgery and cancer will be examined by comparing
subjects undergoing breast surgery because of malignancy vs. prophylactic reasons (aim 1).
Furthermore, the effects of one-week pre-operative protein feeding with or without
enrichment with arginine on post-operative protein metabolism (aim 2) will be investigated
in the cancer group. Variables of interest are: 1. Whole-body and skeletal muscle protein
metabolism, whole body arginine turnover and de-novo arginine production rate, and the
anabolic capacity to feeding(assessed by stable isotope methodology). 2. Body weight, muscle
mass and functional status, score for well-being (assessed by Profile of Mood State and Mini
In the present study, we propose that a nutritional supplement that is high in protein
content and enhanced in arginine will be more effective than a typical commercial
nutritional supplement in diminishing the catabolic effects of surgery in subjects with
cancer, thereby optimizing their quality of life. If this is found to be the case, this
would provide the basis for reformulating the nutritional composition in accord with the
effects of cancer and surgery on protein metabolism.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator)
Net protein balance
end of study
Nicolaas Deutz, M.D., Ph.D.
University of Arkansas
United States: Institutional Review Board
|University of Arkansas for Medical Sciences||Little Rock, Arkansas 72205|