Inclusion Criteria:

- Resolution of all acute toxic effects of prior chemotherapy or radiotherapy or
surgical procedures to National Cancer Institute (NCI) Common Terminology Criteria
for Adverse Events (CTCAE) Version 3.0 grade less than or equal to 1.

- Adequate organ function as defined by the following criteria:

- Serum aspartate transaminase (AST); serum glutamic oxaloacetic transaminase
(SGOT) and serum alanine transaminase (ALT); serum glutamic pyruvic transaminase
(SGPT) less than or equal to 2.5 x local laboratory upper limit of normal (ULN),
or AST and ALT less than or equal to 5 x ULN if liver function abnormalities are
due to underlying malignancy

- Total serum bilirubin less than or equal to 1.5 x ULN

- Absolute neutrophil count (ANC) more than or equal to 1500/mcL

- Platelets more than or equal to 100,000/mcL

- Hemoglobin more than or equal to 9.0 g/dL

- Serum calcium less than or equal to 12.0 mg/dL

- Serum creatinine less than or equal to 1.5 x ULN

- Biopsy-proven disease

- Measurable disease radiographically

- Disease that is deemed surgically unresectable (awaiting orthotopic hepatic
transplantation allowable) and/or metastatic

- Age greater or equal to 18 years

- Life expectancy greater than 16 weeks

- Eastern Cooperative Oncology Group (ECOG) performance status 0, 1 or 2 (Karnofsky
score > 60%)

Exclusion Criteria:

- Major surgery or radiation therapy or chemotherapy within 4 weeks of starting the
study treatment

- NCI CTCAE version 3 grade 3 hemorrhage within 4 weeks of starting the study treatment

- History of or known brain metastases, spinal cord compression, or carcinomatous
meningitis, or evidence of symptomatic brain or leptomeningeal disease on screening
computed tomography (CT) or magnetic resonance imaging (MRI) scan

- Any of the following within the 6 months prior to study drug administration:
myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass
graft, symptomatic congestive heart failure, cerebrovascular accident or transient
ischemic attack, or pulmonary embolism.

- Known brain metastases

- Ongoing cardiac dysrhythmias of NCI CTCAE grade greater than or equal to 2

- Ongoing cardiac dysrhythmias of NCI CTCAE grade greater than or equal to 2, atrial
fibrillation of any grade, or prolongation of the QTc interval to > 450msec for males
or > 470 msec for females

- Hypertension that cannot be controlled by medications (>150/100 mm Hg despite optimal
medical therapy)

- Pre-existing thyroid abnormality with thyroid function that cannot be maintained in
the normal range with medication

- Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome
(AIDS)-related illness or other active infection

- Concurrent treatment on another clinical trial; supportive care trials or
non-treatment trials, e.g. Quality of Life (QOL), are allowed

- Concomitant use of ketoconazole or other agents known to induce CYP3A4

- Concomitant use of theophylline and phenobarbital and/or other agents metabolized by
the cytochrome P450 system

- Ongoing treatment with therapeutic doses of Coumadin (low dose Coumadin up to 2 mg po
daily for thrombo prophylaxis is allowed)

- Pregnancy or breastfeeding. Female subjects must be surgically sterile or be
postmenopausal, or must agree to use effective contraception during the period of
therapy. All female subjects with reproductive potential must have a negative
pregnancy test (serum or urine) prior to enrollment. Male subjects must be surgically
sterile or must agree to use effective contraception during the period of therapy.
The definition of effective contraception will be based on the judgment of the
principal investigator or a designated associate.

- Other severe acute or chronic medical or psychiatric condition or laboratory
abnormality that may increase the risk associated with study participation or study
drug administration, or may interfere with the interpretation of study results, and
in the judgment of the investigator would make the subject inappropriate for entry
into this study.