Inclusion Criteria:

1. Must voluntary sign the informed consent.

2. Age ≥ 18 years.

3. Must be able to comply with the protocol requirements

4. Patient recently diagnosed with Myelodysplastic syndrome red cell transfusion
dependent with low or intermediate -1 risk according IPSS criteria.

5. Red cell transfusion dependent anemia.

6. El patient has to be able to complain with the protocol visits.

7. Women and man must accept to use high efficacy anticonceptive methods

Exclusion Criteria:

1. Pregnancy or breast-feed women.

2. Patients previously received treatment with azacytidine .

3. Patients previously received treatment with erythropoietin agents.

4. Proliferative Chronic myelomonocytic Leukaemia (leukocytes ≥ 12000/mL).

5. Patient with a previous clinical history of another cancer (except for basocellular
carcinoma or spinocellular carcinoma in situ of cervix or breast) except if the
patient is free of symptoms during ≥ 3 years.

6. Cytotoxic chemotherapy or experimental agents usage for myelodysplastic syndrome
treatment during 28 days.

7. Previous haematopoietic transplant.

8. Mielosupresion and antitumoral treatment during the previous 28 days.

9. The following laboratory data:

Absolute neutrophil count < 1000 cel/ml (0.5x 109L) Platelet count < 50000/μL (25 x
109/L) Creatinine > 2.0 mg/dL (177 mmol/L) Aspartate transaminase (AST) or Alanine
transaminase (ALT ) > 5 x the upper limit of normal. Total bilirubin: > 2 mg/dL

10. Patients with B12 vitamin, folic acid and ferrum deficiency.

11. Patient with positive VIH-1.

12. Any other organic or mental illness that could make impossible to sign the Inform
consent or involve risk to the patient.

13. Patient has hypersensitivity previous to beta ,azacytidine, erythropoietin and/or
mannitol.