A Randomized Controlled Trial of Group Psychotherapy Interventions for Cancer Patients
To conduct a randomized controlled trial comparing the efficacy of Meaning-Centered Group
Psychotherapy (MCGP) versus a standardized Supportive Group Psychotherapy (SGP) in reducing
psychological distress (depression and anxiety), end-of-life despair (hopelessness, desire
for hastened death, and suicidal ideation), and improving spiritual well-being and overall
quality of life in a sample patients with advanced cancer.
To assess the relative impact of Meaning-Centered Group Psychotherapy on different aspects
of spiritual well-being (e.g., a sense of meaning and purpose versus spirituality linked to
To examine clinical and demographic variables that may correspond to differential responses
to Meaning-Centered Group Psychotherapy (e.g., potential mediating and moderating influences
such as illness severity, religion and religiosity, level of education, race/ethnicity,
level of pre-intervention social support, presence of pain and physical symptom burden).
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
The primary outcomes to be measured include measures of spiritual well-being (meaning) and psychological distress (depression, hopelessness, optimism quality of life).
William Breitbart, MD
Memorial Sloan-Kettering Cancer Center
United States: Institutional Review Board
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