Dynamic Changes in the Serum Anti-Müllerian Hormone Level During Low-Dose recFSH Administration Further Support Its Role in the Anovulation of Polycystic Ovary Syndrome
Women with PCOS (Rotterdam definition) whom anovulation is resistant to clomiphene citrate
will receive recombinant FSH using the low-dose step-up protocol during only one cycle.
Serum levels of estradiol, AMH, LH, FSH, inhibin B and ultrasound (U/S) parameters will be
assessed twice a week until 3 days after appearance of > 1 dominant follicle(s).The starting
dose of recFSH will be 50 IU/day. In the absence of criteria for dominance (see below) after
14 days at 50 IU/day, recFSH dose will be increased by 25 IU/day every 7 days until
dominance is achieved. Dominance will be defined by the appearance of at least one follicle
>10 mm growing at least 2 mm/day and serum E2> 100 pg/L. Ultrsound examination will
performed with a 7-MHz transvaginal transducer (Sonoline Elegra, Siemens), in real time,
according to a standardized protocol.Serum AMH levels will be assessed using the
second-generation enzyme immunoassay AMH-EIA.
Observational Model: Defined Population, Observational Model: Natural History, Time Perspective: Longitudinal, Time Perspective: Prospective
Didier R DEWAILLY, MD
University Hospital of Lille
France: Institutional Ethical Committee