Differential Diagnosis Between Pancreatic Cancer and Chronic Pancreatitis: Value of the Detection of Urinary Cadmium
- Obtain urine samples and questionnaire data on cadmium exposure in patients with
- Analyze these data to determine risk of pancreatic cancer using urine cadmium levels.
- Analyze these data in conjunction with data on serum CA 19-9, to determine whether
urinary cadmium has clinical utility in predicting pancreatic cancer.
- Determine the sensitivity, specificity, and positive and negative predictive values for
the cadmium test alone, CA 19-9 alone, and both tests together.
OUTLINE: This is a pilot study.
Patients complete a questionnaire over approximately 20 minutes on lifetime exposure to
cadmium, including dietary, occupational, and recreational exposure, smoking history, and
residence. Patients also provide a urine sample that is analyzed by atomic absorption
spectrophotometry. Serum CA 19-9 levels are obtained from medical record if available.
Observational Model: Case Control, Time Perspective: Prospective
Exposure to cadmium, as measured by questionnaire data on dietary, occupational, and recreational exposure to cadmium, and by measurements of cadmium in urine
Gary G. Schwartz, MD, PhD, MPH
Comprehensive Cancer Center of Wake Forest University
United States: Institutional Review Board