Phase III Trial to Compare RadiaPlexRx Hydrogel and Standard-of-Care for Radiation Dermatitis in Breast Cancer Patients
The Study Gels:
RadiaPlexRx (requires a prescription) and Aquaphor (over-the-counter) are both gels that are
designed to treat irradiated (received radiation) breast skin.
These 2 gels contain different ingredients that may make one gel better than the other to
treat irradiated breast skin. RadiaPlexRx contains hyaluronic acid (an ingredient found
naturally in skin), aloe vera, and other ingredients that help the skin heal. Aquaphor is
made of mostly petroleum that helps protect the skin.
Application of Study Gels:
If you decide to participate in this study, the following steps will be taken:
- You will be given detailed instructions on how to apply both of the gels. You should
not apply other gels or lotions on the areas of skin where you will be instructed to
apply the study gels, unless you are instructed to do so by the treating doctor.
- You will receive a supply of both gels (in tubes) with enough to last for the length of
your treatment. You will know which gel is which, but each gel will be labeled with
"outer" or "inner" so that you will know which gel to use on which side. You should
not tell your treating doctor which side of the breast skin is being treated with which
gel so that a fair comparison of the gels can be made.
- You will apply 1 gel to the outer side of the irradiated breast skin and the other gel
to the inner side of the irradiated breast skin.
- If you experience any kind of allergic reaction (such as a rash) to the study gels, you
should notify the study doctor or study staff immediately.
Schedule for Study Gels:
You will need to follow the schedule for applying the gels as follows:
- You will need to apply both gels starting 1 day before the start of radiation
- You will then need to apply both gels for 6 weeks during radiation treatment.
- During the study period (1 day before the start of radiation treatment, during 6 weeks
of radiation treatment), you will need to apply both gels 3 times (in the morning,
afternoon, and evening just before going to sleep) each day at home.
- During the days that you receive radiation treatment, you will be asked to apply the
gels immediately after you receive your radiation treatment. This will count as 1 of
the 3 daily gel applications.
You will have the following tests done during your clinic visits:
- Three (3) sets of photos of your breast skin will be taken (before radiation starts and
during Weeks 3 and 6 of radiation therapy treatment).
- During Weeks 1 through 6, you will go to the clinic to have your skin checked by your
treating physician to learn the effects of each gel on your symptoms. .
- You will need to return any empty tubes of study gel so that new tubes can be given if
you will need more.
Length of Study:
If the treating doctor sees that the irradiated breast skin reacts poorly (does not improve
or gets worse) or you experience any intolerable side effects, you will be taken off this
study. Otherwise, the total time on this study is about 6 weeks.
-During your last week of radiation therapy treatment you will be asked to fill out a
questionnaire about how you felt about each gel.
This is an investigational study. RadiaPlexRx and Aquaphor are both FDA approved and
commercially available. Up to 92 patients will take part in this study. All will be
enrolled at M. D. Anderson.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
Number of Patients using RadiaPlexRx Hydrogel that developed grade 2 or higher radiation dermatitis in breast cancer from adjuvant radiation compared to a petroleum-based gel (Aquaphor) commonly used as best supportive care
Thomas Buchholz, MD
M.D. Anderson Cancer Center
United States: Institutional Review Board
|UT MD Anderson Cancer Center||Houston, Texas 77030|