Germline Genetic Variation and Risk of Chromosome Aberrations Among Mayak Nuclear Workers
Greater understanding of the role of individual variation in response to radiation exposure
might clarify the inconsistent relationship between radiation dose, intermediate markers of
induced DNA damage, and subsequent cancer risk. REB proposes to collaborate with Columbia
University and the Southern Urals Biophysics Institute to elucidate the contribution of
germline genetic variation to the frequency of chromosomal aberrations in a cohort of
Russian nuclear workers with notable and atypical radiation exposures. Our collaborators
are utilizing a new biodosimetry method, termed mBAND, to measure intra-chromosomal
aberrations, a potentially useful biomarker of exposure to high linear energy transfer
radiation such as plutonium. In addition, they will assess inter-chromosomal aberrations
using mFISH (multicolor fluorescent insitu hybridization). As factors other than radiation
dose may influence aberration frequency, REB proposes to add to this DOE-funded study an
investigation of germline genetic variation in DNA repair and other genes in relation to
aberration risk. Mayak nuclear workers (n = approximately 350) employed from 1948-72 will
receive a short questionnaire and have a blood sample drawn while receiving routine annual
medical exams. Germline genotype will be assessed as a risk factor for chromosome
aberration frequency. In this study, we have the opportunity to address scientific
questions regarding radiation carcinogenesis mechanisms at relatively little cost in a
population with rare, higher dose exposures.
Observational
N/A
Martha Linet, M.D.
Principal Investigator
National Cancer Institute (NCI)
United States: Federal Government
999904215
NCT00481793
June 2004
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