Gene Environment Risk Assessment and CRC Screening
- Compare Genetic Epidemiology and Risk Assessment (GERA) feedback vs usual care (UC) in
terms of colorectal cancer (CRC) screening utilization by healthy participants.
- Determine the impact of GERA feedback and UC on psychological distress in these
- Compare GERA feedback vs UC in terms of intention to have CRC screening, perceived CRC
risk, CRC knowledge, salience and coherence of CRC screening, and support for CRC
screening in these participants.
- Identify factors that moderate the impact of GERA feedback on CRC screening
OUTLINE: This is a randomized study. Participants are randomized to 1 of 2 screening arms.
- Arm I: Participants receive standard primary care.
- Arm II: Participants receive standard primary care followed by the Genetic Epidemiology
and Risk Assessment (GERA) intervention. Participants also participate in a discussion
session regarding the GERA including the rationale behind methylenetetrahydrofolate
reductase mutation detection and folate assessment and its relationship to colorectal
All participants undergo a fecal occult blood test 3 weeks after the screening office visit.
PROJECTED ACCRUAL: A total of 1,950 participants will be accrued for this study.
Allocation: Randomized, Primary Purpose: Health Services Research
Comparison of Genetic Epidemiology and Risk Assessment (GERA) feedback vs usual care (UC) in terms of colorectal cancer (CRC) screening utilization
David Weinberg, MD, MSC
Fox Chase Cancer Center
|Fox Chase Cancer Center - Philadelphia||Philadelphia, Pennsylvania 19111-2497|