Know Cancer

or
forgot password

Molecular and Genetic Analysis of Lung Cancer


N/A
N/A
N/A
Open (Enrolling)
Both
Lung Cancer

Thank you

Trial Information

Molecular and Genetic Analysis of Lung Cancer


OBJECTIVES:

- Assess the role of genetic polymorphisms in lung-cancer risk in patients with lung
cancer.

- Assess the role of germline polymorphisms in DNA repair genes, p53 pathway genes, and a
matrix metalloproteinase gene (tumor invasion factor) in lung-cancer risk, after
adjusting for potential confounders.

- Assess the roles of gender and age in the genetic susceptibility of lung cancer.

- Assess the role of genetic polymorphisms in modifying the diet-lung cancer risk
association (gene-diet and exploratory gene-gender-diet and gene-gene-diet
interactions).

- Assess the role of polymorphisms on the risk of developing specific histologic subtypes
of lung cancer in case-only analyses.

- Determine whether continued exposures to mainstream and/or second-hand tobacco smoking
is associated with poorer clinical prognosis in patients treated for lung cancer.

OUTLINE: This is a case-control study.

Blood samples are collected from patients and controls. Samples are analyzed by polymerase
chain reaction for gene polymorphisms. Genes to be studied include GSTP1, GSTM1, GSTT1,
ERCC2, XRCC1, EPHX, NAT-2, p53 gene, CYP1A1, NQO1, MnSOD, and GPX1. Tissue samples collected
from patients undergoing surgery and blood samples are archived for future studies.

Patients and controls complete questionnaires about diet, medical history, and
occupational/environmental history.

PROJECTED ACCRUAL: A total of 3,400 patients and 3,400 controls will be accrued for this
study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Patient:

- Newly diagnosed lung cancer

- Patient at Massachusetts General Hospital (MGH) or Boston Medical Center
Cancer Center

- Control:

- Nonblood-related friend or spouse of the patient

- No specific matching characteristics

- Friend or spouse of other hospital patients

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Metabolic polymorphisms

Safety Issue:

No

Principal Investigator

David C. Christiani, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Massachusetts General Hospital

Authority:

Unspecified

Study ID:

CDR0000450128

NCT ID:

NCT00471978

Start Date:

September 2005

Completion Date:

Related Keywords:

  • Lung Cancer
  • non-small cell lung cancer
  • small cell lung cancer
  • pulmonary carcinoid tumor
  • Lung Neoplasms

Name

Location

Massachusetts General HospitalBoston, Massachusetts  02114-2617
Harvard School of Public HealthBoston, Massachusetts  02115