Inclusion Criteria:

e.

- Patients eligible to be included in this trial were those who histologically
confirmed squamous cell carcinoma of larynx and hypopharynx and they were candidate
of total or partial laryngectomy with or without neck dissection and with negative
history of neck or laryngeal radiation were included in this study.

Exclusion Criteria:

- Patients having recurrences or another primary tumor, and those who underwent
reconstruction with a flap were excluded from the study, because they had been
submitted to prolonged antibiotic administration. Also cases with Diabet mellitus and
Immune suppression or tumor types other than squamous cell carcinoma were excluded
from the study.

- In addition, the following exclusion criteria were taken into account: pregnancy,
hypersensitivity to penicillins or cephalosporins, patients who received a systemic
antibiotic drug within one week prior to the planned procedure, those who had
clinical or laboratory evidence of a preexisting infection or had serious systemic
renal disease.