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Genetic Basis of Hemangiomas


N/A
N/A
N/A
Open (Enrolling)
Both
Hemangioma, Vascular Anomalies

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Trial Information

Genetic Basis of Hemangiomas


WHAT IS INVOLVED IN THE RESEARCH STUDY?

- Buccal smear (cheek cells) or small blood sample (4 mL or 1 teaspoon) from child being
seen in the Dermatology clinic having infantile hemangioma or vascular anomaly

- Buccal smear (cheek cells) or small blood sample (4 mL or 1 teaspoon) from parents of
child

If you and your child agree to be in this study, the following will happen:

1. Informed consent and permission to use or disclose your/your child's health information
for research purposes will be obtained by Dr. Drolet, the principal investigator, or
her research team. You will receive a copy of this consent form.

2. A buccal swab or blood sample will be obtained from you and your child; buccal sampling
involves rubbing the inside of your cheek and removing cells to perform a genetic test
called "Genomewide Association (GWA).

We expect you and your child to be involved in this study until you and your child have the
genetic testing performed.


Study Population

Inclusion Criteria:



- No limit to age

- Diagnosis of infantile hemangioma and/or vascular anomaly

- Unaffected twin sibling

- Each patient's authorized legal guardian must understand the nature of the study and
must provide written informed consent. Each patient must also give assent to study
participation.

Study Population Exclusion Criteria:

- Diagnosis other than infantile hemangioma or vascular anomaly

- If the lesion has resolved and cannot be confirmed as a hemangioma by clinical exam

- If the biologic parents are unwilling or unable to submit DNA samples the child will
be excluded from the DNA study. Therefore, if DNA samples cannot be or are not
obtained from both biologic parents, the child and family will be excluded from the
study.

Type of Study:

Observational

Study Design:

Observational Model: Family-Based

Outcome Measure:

SNP

Outcome Time Frame:

3 years

Safety Issue:

No

Principal Investigator

Beth Drolet, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Medical College of Wisconsin

Authority:

United States: Institutional Review Board

Study ID:

Genetics of Hemangioma

NCT ID:

NCT00466375

Start Date:

April 2007

Completion Date:

May 2016

Related Keywords:

  • Hemangioma, Vascular Anomalies
  • hemangioma
  • vascular anomaly
  • infantile hemangioma
  • Congenital Abnormalities
  • Hemangioma
  • Vascular Malformations

Name

Location

Children's Hospital of WisconsinMilwaukee, Wisconsin  53201