Inclusion Criteria:

- Histologically or cytologically proved breast cancer

- Relapse/recurrent brain metastasis progression after brain radiotherapy

- Presence of brain measurable disease which is defined as at least one brain lesion
that can be measured in at least 1 dimension as ³ 20 mm with magnetic resonance image
(MRI)

- Prior chemotherapy or hormone therapy for metastatic breast cancer is allowed

- Performance status of ECOG 0, 1, 2

- With normal left ventricular ejection fraction and normal ventricular contractility

- Age 21 years or older

- Life expectancy equal or longer than 3 months

- Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

- Prior anthracycline-containing chemotherapy with cumulative dose exceed 400mg/m2
doxorubicin or 750 mg/m2 Epirubicin

- Surgery , radiotherapy, hormonal therapy or chemotherapy within 4 weeks prior to
entering the study

- Prior liposomal doxorubicin treatment

- Concurrent chemotherapy, radiotherapy, hormonal therapy, or other investigational
drug except non-disease related conditions (e.g. insulin for diabetes) during study
period

- Other malignancy with exception of curative treated non-melanoma skin cancer or
cervical carcinoma in situ within 5 years prior to entering the study

- Brain metastases defined as meninges metastases

- Presence of serious concomitant illness which might be aggravated by study
medication:

- Uncontrolled infection (active serious infections that are not controlled by
antibiotics)

- Active cardiac disease e.g. decompensate myocardial infarction within the
6-month period preceding entry into the study.

- History of ventricular arrhythmia or congestive heart failure.

- Presence of abnormal left ventricular ejection fraction

- Hematopoietic function as defined below:

- Hemoglobin＜10g/dl

- ANC＜ 1,500/uL

- Platelets＜100,000/uL

- Organ function as defined below:

- Total bilirubin ＞1.5 × ULN

- ALT / AST＞3 × ULN (＞5.0 x ULN if hepatic metastasis)

- Creatinine ＞1.5 × ULN

- Mental status is not fit for clinical trial

- Pregnant or breast feeding women, or women of child-bearing potential unless using a
reliable and appropriate contraceptive method