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Phase II Study of GW786034 in Patients With Malignant Pleural Mesothelioma

Phase 2
18 Years
Open (Enrolling)
Advanced Malignant Mesothelioma, Localized Malignant Mesothelioma, Recurrent Malignant Mesothelioma

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Trial Information

Phase II Study of GW786034 in Patients With Malignant Pleural Mesothelioma


I. Determine the effect of pazopanib hydrochloride on the proportion of patients with
malignant pleural mesothelioma who are progression-free at 6 months based on the RECIST

II. Determine the clinical toxicities of this drug in this patient population.


I. Determine the objective tumor response status in these patients as measured by the RECIST
criteria or the modified RECIST criteria.

II. Determine the response rate in patients treated with this drug. III. Determine the
effect of this drug on overall survival and time to progression in these patients.

IV. Assess predictive markers of activity of this drug in these patients. V. Assess
serologic markers of target inhibition by this drug in these patients.

OUTLINE: This is a multicenter study.

Patients receive oral pazopanib hydrochloride once daily on days 1-21. Treatment repeats
every 21 days for 2 years in the absence of disease progression or unacceptable toxicity.

Blood is collected at baseline and prior to each course of therapy and analyzed for markers
of angiogenesis.

After completion of study therapy, patients are followed every 3 months.

Inclusion Criteria:

- Histologically or cytologically confirmed malignant pleural mesothelioma:

- Measurable disease

- No progressive disease inside or outside of any prior radiation field

- No symptomatic, untreated, or uncontrolled CNS metastases

- Patients with CNS metastases treated with whole brain radiation (WBRT) may be
enrolled after completion of WBRT

- Patients may begin study therapy as early as the next day after completion

- ECOG performance status 0-2

- Life expectancy >= 12 weeks

- ANC >=1,500/mm^3

- Platelet count >= 100,000/mm^3

- WBC >= 3,000/mm^3

- Bilirubin =< 1.5 times upper limit of normal (ULN)

- AST and ALT =< 2.5 times ULN

- Alkaline phosphatase =< 2.5 times ULN

- Creatinine =< 1.5 times ULN or creatinine clearance >= 50 mL/min

- Proteinuria =< 1+ on 2 consecutive dipsticks taken >= 1 week apart

- No condition that impairs ability to swallow and retain study drug tablets including,
but not limited to, any of the following:

- Gastrointestinal tract disease resulting in an inability to take oral medication

- Requirement for IV alimentation

- Prior surgical procedures affecting absorption

- Active peptic ulcer disease

- No other primary malignancy except for carcinoma in situ of the cervix or
nonmelanomatous skin cancer, unless that prior malignancy was diagnosed and
definitively treated ≥ 5 years ago with no subsequent evidence of recurrence

- Patients with a history of low-grade (Gleason score =< 6) localized prostate cancer
are eligible even if diagnosed within the past 5 years

- No history of allergic reactions attributed to compounds of similar chemical or
biological composition to pazopanib hydrochloride or other agents used in the study

- None of the following concurrent severe and/or uncontrolled medical conditions:

- Serious or nonhealing wound, ulcer, or bone fracture

- Abdominal fistula, diverticulosis, gastrointestinal perforation, or
intra-abdominal abscess within the past 28 days

- Poorly controlled diabetes

- Interstitial pneumonia

- Extensive and symptomatic interstitial fibrosis of the lung

- No cardiovascular illness or complication, including any of the following:

- Any history of cerebrovascular accident within the past 6 months

- History of myocardial infarction (prior electrocardiographic evidence of
myocardial injury)

- History of cardiac arrhythmia (prior electrocardiographic evidence of abnormal
heart rhythm)

- Admission for unstable angina

- Cardiac angioplasty or stenting within the past 12 months

- NYHA class III-IV heart failure

- Asymptomatic NYHA class II heart failure allowed

- QTc prolongation (defined as a QTc interval ≥ 500 msecs) or other significant
electrocardiogram abnormalities

- Venous thrombosis within the past 12 weeks

- No ancillary therapy considered investigational within the past 4 weeks

- No symptomatic, untreated, or uncontrolled seizure disorder

- No uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection or psychiatric illness/social situations that would limit study compliance

- No significant traumatic injury within the past 4 weeks

- No more than 1 prior systemic therapy for malignant pleural mesothelioma

- No major surgery (i.e., laparotomy) or open biopsy within the past 4 weeks

- Insertion of a vascular access device is not considered major or minor surgery

- No minor surgery within the past 2 weeks

- Insertion of a vascular access device is not considered major or minor surgery

- Prior palliative radiotherapy allowed

- No prior palliative radiotherapy to the chest except for a maximum of 3
fractions of radiotherapy for superior vena cava syndrome

- No concurrent therapeutic warfarin

- Low molecular-weight heparin or prophylactic low-dose warfarin allowed

- No other concurrent chemotherapy, immunotherapy, hormonal therapy, or radiotherapy

- No concurrent medications that act through the CYP450 system

- No concurrent combination antiretroviral therapy for HIV-positive patients

- PT/INR/PTT =< 1.2 times ULN

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective nonhormonal contraception

- No uncontrolled infection

- No uncontrolled blood pressure (BP) (defined as systolic BP > 140 mm Hg and/or
diastolic BP > 90 mm Hg in spite of adequate anti-hypertensive therapy)

- No other severe underlying disease that, in the judgment of the investigator, would
limit study compliance

Type of Study:


Study Design:

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Proportion of patients progression-free assessed by Response Evaluation Criteria for Solid Tumors (RECIST)

Outcome Time Frame:

6 months

Safety Issue:


Principal Investigator

Julian Molina

Investigator Role:

Principal Investigator

Investigator Affiliation:

North Central Cancer Treatment Group


United States: Food and Drug Administration

Study ID:




Start Date:

March 2007

Completion Date:

Related Keywords:

  • Advanced Malignant Mesothelioma
  • Localized Malignant Mesothelioma
  • Recurrent Malignant Mesothelioma
  • Mesothelioma



North Central Cancer Treatment Group Rochester, Minnesota  55905