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Tilting of Radioactive Plaques After Initial Accurate Placement for Treatment of Uveal Melanoma


N/A
18 Years
N/A
Open (Enrolling)
Both
Uveal Melanoma

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Trial Information

Tilting of Radioactive Plaques After Initial Accurate Placement for Treatment of Uveal Melanoma


Episcleral plaque radiotherapy is a common treatment for uveal melanoma and results in local
tumor control in most cases. However, local failure has been reported in a substantial
proportion of patients. Since local failure greatly increases the risk of metastatic death,
identifying and correcting the causes of local treatment failure are of paramount
importance. Poor plaque localization is an important contributing factor to local failure.
With the aid of intraoperative ultrasonography, most malpositioned plaques can be identified
and readjusted at the time of plaque insertion. However, little is known about plaque
movement during the 4-5 days of brachytherapy, which could also contribute to local failure.
To address this question, we perform intraoperative B-scan ultrasonography at the time of
iodine-125 radioactive plaque insertion and removal in uveal melanoma patients.


Inclusion Criteria:



- All patients with uveal melanoma treated with brachytherapy

Exclusion Criteria:

- Ciliary melanoma

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Plaque tilt using intraoperative ultrasonography

Outcome Time Frame:

End of study

Safety Issue:

No

Principal Investigator

J W Harbour, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Washington University School of Medicine

Authority:

United States: Institutional Review Board

Study ID:

HRPO# 07-0092

NCT ID:

NCT00459849

Start Date:

July 2000

Completion Date:

July 2007

Related Keywords:

  • Uveal Melanoma
  • Melanoma
  • Brachytherapy
  • Ultrasonography
  • Melanoma
  • Uveal Neoplasms

Name

Location

Washington University in St. Louis School of MedicineSt. Louis, Missouri  63110