Significant Intracellular NIS Protein Associated With Low Levels of NIS Messenger RNA in Malignant Thyroid Tumors
The aim of this study was to quantify NIS transcript levels by real time PCR and to
determine the presence and cellular localization of NIS protein by immunohistochemistry, in
benign and malignant thyroid tumor cells and to compare with their paired surrounding
non-tumoral cell. NIS expression was also compared to that of the TSHR
Observational
Additional Descriptors: Convenience Sample, Primary Purpose: Screening, Time Perspective: Cross-Sectional, Time Perspective: Prospective
Ana K Sodré
Principal Investigator
University of São Paulo
Brazil: Ministry of Health
PRN736/02
NCT00459498
April 2002
October 2006
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