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Significant Intracellular NIS Protein Associated With Low Levels of NIS Messenger RNA in Malignant Thyroid Tumors


N/A
18 Years
80 Years
Not Enrolling
Both
Tumors

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Trial Information

Significant Intracellular NIS Protein Associated With Low Levels of NIS Messenger RNA in Malignant Thyroid Tumors


The aim of this study was to quantify NIS transcript levels by real time PCR and to
determine the presence and cellular localization of NIS protein by immunohistochemistry, in
benign and malignant thyroid tumor cells and to compare with their paired surrounding
non-tumoral cell. NIS expression was also compared to that of the TSHR


Inclusion Criteria:



- PAtients with thyroid tumors undergoing surgery for total or partial thyroidectomy

Exclusion Criteria:

- Pregnancy

Type of Study:

Observational

Study Design:

Additional Descriptors: Convenience Sample, Primary Purpose: Screening, Time Perspective: Cross-Sectional, Time Perspective: Prospective

Principal Investigator

Ana K Sodré

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of São Paulo

Authority:

Brazil: Ministry of Health

Study ID:

PRN736/02

NCT ID:

NCT00459498

Start Date:

April 2002

Completion Date:

October 2006

Related Keywords:

  • Tumors
  • NIS
  • thyroid adenoma
  • thyroid cancer
  • Iodine uptake
  • expression
  • Thyroid Neoplasms

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