Adolescent Diet, Hormones and Breast Cancer Susceptibility
- Determine the long-term effect of the Dietary Intervention Study in Children (DISC) to
lower total fat and saturated fat intake during adolescence on serum progesterone
levels in young women previously enrolled in the DISC study.
- Determine the long-term effect of the DISC intervention on serum estradiol levels in
- Determine the long-term effect of the DISC intervention on bone mineral density in
- Determine the long-term effect of the DISC intervention on breast density in these
- Determine the long-term effect of the DISC intervention on the prevalence of metabolic
syndrome in these women.
OUTLINE: This is a multicenter study.
Patients undergo fasting blood collection on day 1 for assessment of serum hormones
(progesterone, estradiol), lipids, lipoproteins, and fasting glucose. Patients also undergo
blood pressure, height, weight, and waist circumference measurements. Patient then receive a
snack and complete the Modifiable Activity questionnaire, Center for Epidemiological Studies
Depression Scale short form, Spielberger State-Trait Anxiety Inventory, and Dietary
Intervention Study in Children Medical History questionnaire (including demographics,
medical history, menstrual history, medications, reproductive history, dietary supplements,
alcohol and tobacco use, and family history of cancer). Patients also undergo dual-energy
x-ray absorptiometry (DEXA) and MRI to measure bone and breast density. Patients complete an
in-person 24-hour dietary recall using the Nutrition Data System for Research on day 1 and
via telephone once in weeks 2 and 3.
Day 1 is scheduled during the patient's luteal phase of menstrual cycle. After completion of
study, patients contact the clinic to report start of next menses.
PROJECTED ACCRUAL: A total of 301 patients will be accrued for this study.
Time Perspective: Prospective
Mean serum progesterone level in women not using hormonal contraceptives
Joanne Dorgan, PhD, MPH
Fox Chase Cancer Center
United States: Federal Government
|University of Minnesota Cancer Center||Minneapolis, Minnesota 55455|
|Holden Comprehensive Cancer Center at University of Iowa||Iowa City, Iowa 52242-1002|
|Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins||Baltimore, Maryland 21231-2410|
|Kaiser Permanente Center for Health Research||Portland, Oregon 97227-1098|
|Children's Hospital of New Orleans||New Orleans, Louisiana 70118|
|UCSF Comprehensive Cancer Center||San Francisco, California 94115|
|UMDNJ University Hospital||Newark, New Jersey 07103|
|Robert H. Lurie Comprehensive Cancer Center at Northwestern University||Chicago, Illinois 60611|
|Fox Chase Cancer Center - Philadelphia||Philadelphia, Pennsylvania 19111-2497|
|Maryland Medical Research Institute||Baltimore, Maryland 21210|