Inclusion Criteria

Inclusion criteria:

- Male or female patients aged ≥ 18 years old

- Diagnosis of Philadelphia chromosome positive, chronic phase chronic myeloid leukemia

- Prior treatment with at least two BCR-ABL tyrosine kinase inhibitors with
demonstrated resistance to the most recent kinase inhibitor therapy.

- Patients with a history of intolerance to one BCR-ABL kinase inhibitors will be
considered eligible to enter the study if they demonstrate resistance to their most
recent BCR-ABL kinase inhibitor.

- Patients who are intolerant of at least 2 BCR-ABL kinase inhibitors will be
considered eligible to enter this study if they also demonstrate resistance to or
intolerance of interferon-alpha (IFN-α) by the same criteria defined above.

- Patients must have adequate laboratory values

- Baseline measurement of left ventricular ejection fraction [assessment of the hearts
ability to pump effectively]

- Assessment of patients ability to perform every day activities. Assessment by the
ECOG [Eastern Cooperative Oncology Group] Performance Status

Exclusion criteria:

- A candidate for hematopoietic stem cell transplantation

- Prior therapy with certain medications

- Patients with a prior history of accelerated phase or blast crisis CML

- Impaired cardiac function or clinically significant cardiac diseases

- Concomitant use of certain medications

- Impairment of GI function or GI disease

- Patients with unresolved diarrhea

- Patients who have received chemotherapy, any investigational drugs or undergone
major surgery < 4 weeks prior to starting study drug or who have not recovered from
side effects of such therapy

- Patients who have received a BCR-ABL tyrosine-kinase inhibitor within 1 week of first
treatment with LBH589

- Women who are pregnant or breast feeding or women of childbearing potential not using
an effective method of birth control

- Male patients whose sexual partners are women of child bearing potential not using
effective birth control

Other protocol-defined inclusion/exclusion criteria may apply