Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically or cytologically confirmed carcinoma of the breast

- CNS metastases (i.e., brain parenchymal lesions and/or leptomeningeal disease),
meeting 1 of the following criteria:

- Recurrent or progressive CNS metastases after whole brain radiotherapy

- If only evaluable site of CNS progression has been previously treated with
stereotactic radiosurgery, radiation necrosis must be excluded by
radiographic (e.g., positron emission tomography scan or magnetic resonance
spectroscopy) or histologic assessment

- Newly diagnosed, untreated, asymptomatic brain or leptomeningeal metastases

- Patient must be neurologically stable, as demonstrated by a stable dose of steroids
and anticonvulsants for ≥ 1 week prior to obtaining baseline gadolinium-enhanced MRI
of the brain and/or ≥ 1 week prior to beginning study treatment

- No CNS complications requiring urgent neurosurgical intervention (e.g., resection or
shunt placement)

- Hormone receptor status not specified

PATIENT CHARACTERISTICS:

- Male or female

- Menopausal status not specified

- Karnofsky performance status 60-100%

- Life expectancy ≥ 3 months

- Absolute neutrophil count > 1,500/mm^3

- Hemoglobin > 9.0 g/dL

- Platelet count > 100,000/mm^3 (red blood cell transfusion and repeat evaluation
allowed)

- Bilirubin < 1.5 times upper limit of normal (ULN)

- AST and ALT < 2.5 times ULN

- Alkaline phosphatase < 2.5 times ULN

- Creatinine < 1.5 times ULN

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 3 months after
completion of study therapy

- No known hypersensitivity to epothilones

- No peripheral neuropathy > grade 1

- No unresolved diarrhea within the past 7 days

- Grade 0 diarrhea required at study entry

- No concurrent serious medical illness (e.g., HIV positivity or active hepatitis B or
C)

- No severe cardiac insufficiency (e.g., New York Heart Association class III-IV heart
disease) with uncontrolled and/or unstable cardiac or coronary artery disease

- No active or suspected acute or chronic uncontrolled infection, including abscess or
fistulae

- No other malignancy within the past 3 years except curatively treated nonmelanoma
skin cancer, prostate cancer, or carcinoma in situ of the cervix

- No history of noncompliance to medical regimens or inability or unwillingness to
return for all scheduled visits

- No contraindications to MRI, including any of the following:

- Pacemaker

- Ferromagnetic implants

- Claustrophobia

- Extreme obesity

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- More than 2 weeks since prior noncytotoxic drugs (e.g., small molecule-targeted
drugs) and recovered

- More than 3 weeks since prior cytotoxic chemotherapy (6 weeks for nitrosoureas or
mitomycin C) and recovered

- More than 3 weeks since prior intracranial surgery and recovered

- More than 4 weeks since prior radiotherapy and recovered

- More than 4 weeks since prior major surgery

- More than 28 days since prior investigational compounds or drugs

- No prior epothilones

- No concurrent known diarrheagenic agents

- No other concurrent anticancer agents, including investigational agents, biological
agents, or chemotherapy

- No other concurrent experimental therapies

- Concurrent hormone therapy and/or trastuzumab (Herceptin®) allowed

- No concurrent Coumadin® or other agents containing warfarin

- Low dose Coumadin® (≤ 1 mg) for prophylactic maintenance of indwelling lines or
ports allowed

- No concurrent radiotherapy for central metastases (e.g., vertebral or mediastinal
metastases)

- Concurrent radiotherapy for local peripheral metastases not being used as marker
lesions allowed

- No concurrent prophylactic hematopoietic growth factors during course 1

- No concurrent herbal or nontraditional medications