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The Biodistribution of N-{4-[3'-[F-18] Fluoroethylphenyl)Amino]-6-quinazolinyl}-Acrylamide ([F-F18]FEQA) in Patients With Advanced Non-Small-Cell Lung Cancer (NSCLC) and in Healthy Subjects: A Pilot Study


N/A
18 Years
N/A
Open (Enrolling)
Both
Lung Cancer

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Trial Information

The Biodistribution of N-{4-[3'-[F-18] Fluoroethylphenyl)Amino]-6-quinazolinyl}-Acrylamide ([F-F18]FEQA) in Patients With Advanced Non-Small-Cell Lung Cancer (NSCLC) and in Healthy Subjects: A Pilot Study


OBJECTIVES:

- Determine the biodistribution of fluorine F 18 FEQA in patients with stage III or IV
non-small cell lung cancer (NSCLC) and in healthy participants.

- Determine whether fluorine F 18 FEQA can be used as an imaging agent with positron
emission tomography in patients with stage III or IV NSCLC.

OUTLINE: This is a pilot study.

Patients and healthy participants receive fluorine F 18 FEQA IV and then undergo whole-body
dynamic scans comprising positron emission tomography.

Blood is collected during and after imaging to measure radioactivity.

PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.


Inclusion Criteria:



- Must meet 1 of the following criteria:

- Diagnosis of non-small cell lung cancer by CT scan, bone scan, or biopsy

- Stage III or IV disease

- Clinically assessed with

- Healthy participant

Exclusion Criteria:

Type of Study:

Interventional

Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

Biodistribution of fluorine F 18 FEQA

Safety Issue:

No

Principal Investigator

Johannes Czernin, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Jonsson Comprehensive Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

CDR0000529363

NCT ID:

NCT00444223

Start Date:

May 2004

Completion Date:

Related Keywords:

  • Lung Cancer
  • stage IIIA non-small cell lung cancer
  • stage IIIB non-small cell lung cancer
  • stage IV non-small cell lung cancer
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms

Name

Location

Jonsson Comprehensive Cancer Center at UCLALos Angeles, California  90095-1781