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Phase 4
18 Years
Not Enrolling
Lung Cancer

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Trial Information

This prospective randomized study analyzed 80 patients that underwent flexible bronchoscopy.
Patients were randomly assigned to four groups of 20 patients each according to the
anesthetic combination used: 200 mg topical lidocaine (LID group); 200 mg topical lidocaine
and 2 mg/kg propofol (PPF group); 200 mg topical lidocaine and 20 mcg/kg alfentanil (ALF
group); or 200 mg topical lidocaine and 0.05 mg/kg midazolam (MID group). Scores were
assigned to patients according to the different variables observed during the endoscopic
procedure; the lower the score, the lower the complication index.

Inclusion Criteria:

- The patients included in this study were referred to FBC for the investigation of
bronchial carcinoma (diagnostic procedure).

- Patients included in the study were classified as ASA I, II and II according to the
anesthetic risk classification of the American Society of Anesthesiologists (ASA).

Exclusion Criteria:

- ASA IV classification of anesthesiology risk

- procedure that lasted longer than 15 minutes

- indication of therapeutic bronchoscopy

- cardiac arrhythmia and / or hypoxemia detected at admission.

Type of Study:


Study Design:

Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Single Blind, Primary Purpose: Treatment

Principal Investigator

Andre GS Leite, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Brazilian Society of Thoracic Surgery


Brazil: Ministry of Health

Study ID:




Start Date:

Completion Date:

Related Keywords:

  • Lung Cancer
  • alfentanil
  • anesthesia
  • bronchoscopy
  • lidocaine
  • midazolam
  • propofol.
  • Lung Neoplasms