GIMEMA LAL 0496: High-Dose Anthracycline in the Induction Regimen for the Treatment of Adult Acute Lymphoblastic Leukemia. A Prospective Multicentric GIMEMA Trial.
The present trial is a prospective multicentric GIMEMA study, in which adult ALL patients
are extensively analyzed at diagnosis by a multiparametric approach including CC and
molecular analysis for the following gene rearrangements: BCR-ABL, MLL-AF4, E2A-PBX1,
TEL-AML1, MLL, p15 and p16 deletion in order to give place to a carefully characterization
of the genetic lesions occurring in adult ALL and to evaluate their prognostic significance
in a large cohort of patients homogeneously treated.
This study requires a central handling and analysis of bone marrow (BM) or peripheral blood
samples at presentation.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Franco Mandelli, Prof.
Università degli Studi di Roma "La Sapienza"
Italy: The Italian Medicines Agency