Inclusion Criteria:

- Patients ≥18 years with RA, RARS, RAEB (blasts <10%)

- Hb< 10g/dl > of 2 months or transfused since less 2 months

- Hb<12g/dl > of 2 months and thrombocytopenia defined by platelets < 50 000/mm3, or
neutropenia<10 000mm3

- For women of child bearing age, necessity of contraception during all the duration of
the study

Exclusion Criteria:

- Patient with lung disease, cardiac, neurological, gastro-intestinal or genito -
urinary disorders not connected to genito -urinary not connected to myelodysplasia

- Patient having received intensive chemotherapy in the 3 months before inclusion in
the protocol

- RAEBt

- RAEB >10% blasts

- Treatment with rHu-Epo, darbepoetin ou rHu-GCSF , 2 months before inclusion

- Patient presenting an iron , B12 vitamin or folic acid uncorrected deficit

- CMML

- Uncontrolled systemic hypertension

- creatinine clearance < 300 µM/L

- Pregnant patient or in period of lactation

- Life expectancy < 6 months