Inclusion Criteria:

- Male or female subjects older than 30 years of age.

- Subjects with a photodamage grade of at least 4 on the Griffiths photonumeric scale
(symmetrical photodamage on the two target areas)

- Subjects with mottled hyper-pigmentation on the face

- Subjects willing and capable of cooperating to the extent and degree required by the
protocol

- Subjects must read the Patient Information Sheet and read and sign the Informed
Consent form prior to any study related procedures.

Exclusion Criteria:

- Subjects who are at risk in terms of precautions, warnings, and contra-indication in
the package insert for Metvix®

- Subjects with suspected porphyria

- Subjects with specific wash-out period for interfering treatments

- Subjects requiring concurrent treatment that would interfere with study objectives
and/or evaluations