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Genetic Basis of Neuroblastoma Tumorigenesis


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Open (Enrolling)
Both
Neuroblastoma

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Trial Information

Genetic Basis of Neuroblastoma Tumorigenesis


OBJECTIVES:

- Perform a whole genome scan for association of neuroblastoma with single nucleotide
polymorphisms (SNP) and SNP haplotypes.

- Identify true disease-associated SNP alleles using a customized genotyping platform
enriched for haplotype analyses in an independent sample set.

- Validate disease-associated SNP alleles and haplotypes in a final independent sample
set.

- Identify neuroblastoma predisposition genes.

OUTLINE: This is a multicenter study. Participants are stratified according to presence of
high-risk disease (yes vs no) and MYCN amplification (yes vs no).

DNA samples are derived from participants' banked blood or uninvolved bone marrow. A whole
genome scan of DNA samples is employed to identify candidate single nucleotide polymorphisms
(SNPs). The candidate SNPs are investigated, using a gene-centric haplotyping approach, to
identify 10-20 true disease-associated alleles. The disease-associated alleles are again
investigated, using a gene-centric haplotyping approach, to validate 5-10 disease-associated
SNPs. SNPs are then analyzed for heritable predisposition.

Patients do not receive the results of the genetic testing.

A certificate of confidentiality protecting the identity of research participants in this
project has been issued by the Children's Oncology Group.

PROJECTED ACCRUAL: A total of 4,675 patients and 4,675 controls will be accrued for this
study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Patient:

- Diagnosis of neuroblastoma

- Banked constitutional and genomic DNA within COG-ANBL00B1 Neuroblastoma
Biology protocol or another COG Biology Protocol

- At least 1.0 μg of DNA available

- Control (age, race, and gender-matched):

- No diagnosis of cancer

- May have other conditions, including any of the following:

- Asthma

- Inflammatory bowel disease

- Attention-deficit disorder

- Obesity

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Neuroblastoma predisposition genes

Safety Issue:

No

Principal Investigator

John M. Maris, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Children's Hospital of Philadelphia

Authority:

Unspecified

Study ID:

CDR0000522985

NCT ID:

NCT00436696

Start Date:

December 2006

Completion Date:

Related Keywords:

  • Neuroblastoma
  • disseminated neuroblastoma
  • localized resectable neuroblastoma
  • localized unresectable neuroblastoma
  • recurrent neuroblastoma
  • regional neuroblastoma
  • Neuroblastoma

Name

Location

University of Mississippi Cancer ClinicJackson, Mississippi  39216-4505