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Pilot, Multicenter and Prospective Study of the Natural Killer Index From Hematopoietic Stem Cell Graft at a Genotypic, Phenotypic and Functional Level


N/A
1 Year
N/A
Open (Enrolling)
Both
Acute Lymphoblastic Leukemia, Acute Myeloblastic Leukemia, Chronic Myeloid Leukemia

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Trial Information

Pilot, Multicenter and Prospective Study of the Natural Killer Index From Hematopoietic Stem Cell Graft at a Genotypic, Phenotypic and Functional Level


Inclusion Criteria:



- Age superior to 1 year

- Patient that will be treated by an HSC graft

- Initial pathology of recipient: acute lymphoblastic leukemia, acute myeloblastic
leukemia, chronic myeloid leukemia

Exclusion Criteria:

- Patient already included in a study with an exclusion period

- HIV + or HCV + serology during pre-graft analysis

- Patient already treated by an allograft of HSC

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Outcome Measure:

Estimate in the pilot study the percentage of different NK cell populations during hematopoietic reconstitution after HSCT with regard to the KIR and HLA genotypes of donor / recipient

Outcome Time Frame:

J60 post-HSCT

Safety Issue:

No

Principal Investigator

Fran├žoise Mechinaud, md

Investigator Role:

Principal Investigator

Investigator Affiliation:

CHU de Nantes

Authority:

France: Ministry of Health

Study ID:

BRD 06/6-N

NCT ID:

NCT00435864

Start Date:

April 2007

Completion Date:

July 2012

Related Keywords:

  • Acute Lymphoblastic Leukemia
  • Acute Myeloblastic Leukemia
  • Chronic Myeloid Leukemia
  • recipient of a HSC graft in Acute Myeloblastic Leukemia therapy
  • recipient of a HSC graft in others pathologies treated in hematology of Nantes university hospital or Angers university hospital
  • donors are healthy subjects
  • Leukemia
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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