Inclusion Criteria

- INCLUSION CRITERIA:

AGE: Patients must be greater than or equal to 1 years and less than or equal to 30 years
of age in order to encompass a broad range of ages in children as well as to capture the
young adult population which is highly represented in many of these types of sarcomas
being studied.

DIAGNOSIS: Histologically confirmed solid tumors, which may include but are not limited to
rhabdomyosarcoma and other soft tissue sarcomas, Ewing's sarcoma family of tumors,
osteosarcoma, neuroblastoma, Wilm's tumor, Hodgkin's or non-Hodgkin's lymphoma. Patients
with primary or untreated metastatic CNS tumors or primary or metastatic hepatic tumors
will not be treated on this study.

MEASURABLE/EVALUABLE DISEASE: Patients must have measurable or evaluable tumors.

PRIOR THERAPY:

The patient's cancer must have relapsed following or failed to respond to standard
therapy, and the patient's current disease state must be one for which there is no known
curative therapy or therapy proven to prolong survival with an acceptable quality of life.

Patients must have completed their last dose of irradiation, chemotherapy, monoclonal
antibody, or investigational therapy at least 4 weeks prior to enrollment or their last
dose of nitrosurea (CCNU, BCNU) 6 weeks prior to enrollment. For patients who have
undergone autologous stem cell transplantation, at least 3 months must have elapsed since
transplant.

Patients must have recovered from the toxic effects of all prior therapy prior to
enrollment.

Patients must have been off colony stimulating factors (e.g. G-CSF, GM-CSF, Epo) for at
least 72 hours prior to enrollment.

Patients must have completed any biological therapy (including investigational therapies)
at least 7 days prior to study entry.

PERFORMANCE STATUS: Patients greater than 10 years old must have a Karnofsky Score of
greater than or equal to 50 and children less than or equal to 10 years old must have a
Lansky score of greater than 50. Patients who are unable to walk because of paralysis or
weakness, but who are up in a wheelchair will be considered ambulatory for the purpose of
calculating the performance score.

HEMATOLOGIC FUNCTION: Patients must have adequate bone marrow function, defined as a
peripheral absolute granulocyte count of greater than or equal to 1000/microliter,
hemoglobin greater than or equal to 8 gm/dl, and a transfusion independent platelet count
greater than or equal to 75,000/microliter.

Cardiac Function: Patients must have an ejection fraction of greater than 40% via MUGA or
Echo or a shortening fraction greater than 27% by Echo and must not have had a history of
congestive heart failure.

HEPATIC FUNCTION: Aspartate transaminase (AST) and alanine transaminase (ALT), less than
or equal to 2.5-fold the upper limit of normal (ULN). Direct bilirubin within normal
limits.

RENAL FUNCTION: Patients must have normal age-adjusted serum creatinine (see Table below)
OR a creatinine clearance greater than or equal to 60 mL/min/1.73 m(2).

Age Less than or equal to 5 with a max serum creatinine (mg/dl) of 0.8

Age less than 5 less than or equal to 10 with a max serum creatinine (mg/dl) of 1.0

Age less than 10 less than or equal to 15 with a max serum creatinine (mg/dl) of 1.2

Less than 15 with a max serum creatinine (mg/dl) of 1.5

INFORMED CONSENT: All patients or their legal guardians (if the patients is less than18
years old) must sign a document of informed consent (Pediatric Oncology Branch, NCI
screening protocol for NIH patients) prior to performing studies to determine patient
eligibility. After confirmation of eligibility, all patients or their legal guardians must
voluntarily sign the IRB approved protocol specific informed

this study and their willingness to receive the therapy and to undergo the research
studies involved including pharmacokinetic studies. The consent must be signed before any
protocol related studies are performed (This does not include routine laboratory tests or
imaging studies required to establish eligibility). When appropriate, pediatric patients
will be included in all discussions in order to obtain verbal assent. Assent will be
obtained according to local IRB requirements.

DURABLE POWER OF ATTORNEY (DPA): Patients who are greater than or equal to 18 years of age
will be offered the opportunity to assign a DPA so that another person can make decisions
about their medical care if they become incapacitated or cognitively impaired.

BIRTH CONTROL: Patients of childbearing or child-fathering potential must be willing to
use a medically acceptable form of birth control, which includes abstinence, while they
are being treated on this study and for 60 days following the last dose.

EXCLUSION CRITERIA:

Clinically significant unrelated systemic illness, such as serious infections or organ
dysfunction, which in the judgment of the Principal or Associate Investigators would
compromise the patient's ability to tolerate the agents in this trial or are likely to
interfere with the study procedures or results.

Patients with a history of allogeneic bone marrow transplantation. Patients who have
received autologous stem cell transplantation are eligible greater than 3 months after
completion of therapy if they meet other eligibility requirements.

Patients with hepatic tumors or metastases are excluded due to the potential for
hepatotoxicity with agents that target the TRAIL-R pathway. Patients with primary CNS
tumors will be excluded due to unknown penetration into the CNS.

Untreated CNS metastases will render the patient ineligible however patients with a
previous history of CNS metastases are eligible if: the metastases have been treated with
surgery and/or radiotherapy, are clinically stable as evidenced by no requirements for
corticosteroids, the patient has no evolving neurologic deficits and no change in residual
brain abnormalities without specific therapy over 6 weeks.

Pregnant or breastfeeding females are excluded because the risks of lexatumumab to the
developing fetus or nursing child are unknown.

Patients currently receiving other investigational agents.

History of any infection requiring hospitalization or parenteral antibiotics within 2
weeks of study entry.

Co-existing medical illness that would place the subject at undue risk.

On immunosupressant therapy (with the exception of prednisone up to 10 mg/day, or
dexamethasone up to 4 mg/day), or with known human immunodeficiency virus (HIV) infection
or hepatitis B or C. Subjects with immune deficiency are excluded due to their increased
risk of life threatening toxicity when treated with anticancer agents.