BRAF and Nevi.Nevi Are Common Benign Pigmented Tumors of the Skin. Mutations in So-called BRAF and NRAS Genes Genes Appear to be Initiating Events Responsible for the Formation of Nevi.
The investigations to this study will verify whether small CMN, "early" AMN and dermal nevi,
characterized by globular pattern differ in their genetic alterations compared to reticular
typed nevi. It will be expected that globular typed nevi and eventually dermal nevi lack
B-RAF mutations whereas reticular nevi show alterations in the B-RAF gene. Study location:
Allocation: Non-Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Frequency of BRAF Mutations Among Nevi
All nevi were analyzed for BRAF mutations using the (less sensitive) Sanger method. A random subset of nevi was also analyzed using the (more sensitive) Ultradeep pyro-sequencing method (UDPS). The frequency is reported here as the number of BRAF mutations found by each method.
up to 30 months
Iris Zalaudek, MD
Department of Dermatology, Medical University of Graz