Trial Information

Incidence, Prevalence, Spectrum of HPV-Types, and Viral Load Determination of High-Risk Human Papillomavirus Infection of the Oral Cavity in HIV-Infected Men Who Have Sex With Men

Human papillomavirus (HPV)-infection belong to the most common sexually transmitted diseases
worldwide. Estimated prevalences of subclinical genital HPV-infection in the immunocompetent
sexually active population range from 10 to above 50%. Genetic or iatrogenic
immunosuppression is known to play a decisive role in the initiation of a variety of
cutaneous neoplasias and their precursor lesions. In this context, HPV-associated anogenital
malignancies occur with high frequency in patients with HIV-infection. In several studies,
perianal HPV-infections have been detected in up to 90% of HIV-positive men and a high
incidence of anal dysplasia has been reported in these patients. The data concerning the
incidence of oral HPV-infection in HIV-positive men, especially in the era of highly
antiretroviral therapy, are conflicting. Thus, this prospective study mainly focuses on the
incidence and prevalence of oral HPV-infection, spectrum of HPV-types, and oral high-risk
HPV viral load in HIV-positive men.