Randomized Controlled Trial Comparing the Effect of GnRH Agonist and Antagonist Ovarian Stimulation Protocols in PCOS Patients
Women with polycystic ovarian syndrome (PCOS) represent a group of patients at high risk of
developing ovarian hyperstimulation syndrome (OHSS), an iatrogenic complication of ovarian
stimulation during IVF treatment. In contrast to mild OHSS, severe OHSS is a
life-threatening complication, characterized by massive ovarian enlargement, ascites,
pleural effusion, oliguria, haemoconcentration and thromboembolic phenomena. Currently, no
curative therapy for OHSS is available and thus prevention is considered the most effective
“treatment”. Several measures have been adopted to reduce the occurrence of the syndrome,
the most effective being cycle cancellation and withholding of human chorionic gonadotropin
(hCG), which seems to be the most critical factor for the development of OHSS.
COMPARISON: This study aims to compare the development and severity of OHSS, as well as
ongoing pregnancy rates in PCOS patients who received a flexible GnRH antagonist (Ganirelix)
protocol vs a long GnRH agonist (Arvekap) protocol of ovarian stimulation.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Development of OHSS
Tryfon Lainas, PhD
Principal Investigator
Eugonia
Greece: National Organization of Medicines
ag vs antag PCOS
NCT00417144
November 2003
May 2007
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