Evaluation of Normal Tissue Toxicities in Head and Neck Cancer Patients Receiving Intensity Modulated Radiotherapy (IMRT)
OBJECTIVES:
Primary
- Assess salivary function in patients with advanced head and neck cancer treated with
intensity-modulated radiotherapy (IMRT) by measuring stimulated saliva production at 6
and 12 months after completion of therapy.
- Compare salivary function in these patients to salivary function in historical
controls.
Secondary
- Assess auditory, swallow, and voice function and quality of life of these patients
before and after IMRT or chemoradiotherapy.
- Advance experience with IMRT/tomotherapy and improve field design for irradiating head
and neck cancer in an effort to reduce radiation dose and minimize effects on
surrounding normal tissue.
OUTLINE: This is a prospective study.
Patients undergo standard of care high-dose intensity-modulated radiotherapy (IMRT) to the
head and neck.
Patients undergo baseline and post-treatment testing of auditory, salivary, swallow, and
voice function as well as quality of life evaluation.
Patients are evaluated for radiation-induced toxicities at 1, 6, and 12 months after
completion of IMRT.
PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study.
Observational
N/A
Stimulated saliva production at 6 months after completion of intensity-modulated radiotherapy (IMRT)
No
Paul M. Harari, MD
Study Chair
University of Wisconsin, Madison
United States: Federal Government
CDR0000515323
NCT00415025
June 2004
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