Inclusion Criteria:

- Pathologic confirmation of pancreatic adenocarcinoma

- 18 years of age or older

- At least one measurable site of disease according to RECIST criteria that has not
been previously irradiated. If patient has had previous radiation to the marker
lesion(s), there must be evidence of progression since the radiation.

- Treated with gemcitabine-based chemotherapy with documented tumor progression on
gemcitabine or intolerance to gemcitabine.

- Prior treatment with no more than 1 prior chemotherapy regimen for metastatic
disease.

- Minimum of two weeks since any major surgery, completion of radiation, or completion
of all prior systemic anti-cancer therapy.

- ECOG performance status 0-1.

- Life expectancy of greater than 12 weeks.

- Adequate bone marrow and liver function.

- Must be able to swallow tablets.

Exclusion Criteria:

- Prior treatment with an investigational drug within the preceding 4 weeks.

- Prior treatment with an inhibitor of mTOR

- Chronic treatment with systemic steroids or another immunosuppressive agent

- More than one prior chemotherapy treatment for metastatic disease

- Uncontrolled brain or leptomeningeal metastases, including patient who continue to
require glucocorticoids for brain or leptomeningeal metastases.

- Other malignancies within the past 3 years except for adequately treated carcinoma of
the cervix or basal or squamous cell carcinomas of the skin

- Patients with chronic renal insufficiency

- Other concurrent severe and/or uncontrolled medical disease which could compromise
participation in the study.

- Known history of HIV seropositivity

- Impairment of gastrointestinal function or gastrointestinal disease that my
significantly alter the absorption of RAD001.

- Active, bleeding diathesis or an oral vitamin K antagonist medication

- Women who are pregnant or breast feeding