Inclusion Criteria:

- Solid tumors confirmed histologically whose tumors are refractory to standard
therapy, or for whom standard or curative therapy does not exist

- Patients from whom paired melanoma biopsies are planned must have a V600E+ BRAF
mutation confirmed prior to the administration of PLX4032

- Previous chemotherapy, immunotherapy, or radiation therapy must have been completed
at least 2 weeks prior to starting PLX4032 therapy, and all associated toxicity must
be resolved prior to administration of PLX4032

- Patients in the Extension cohorts (melanoma or adenocarcinoma of the colon or rectum)
must have both a V600E+ BRAF mutation and measurable disease (by RECIST V 1.0
criteria) prior to the administration of PLX4032. All patients enrolled must provide
archival or fresh melanoma tumor biopsy for confirmation of V600E+ BRAF mutation
status by TaqMan assay

- ECOG performance status 0 or 1

- Life expectancy ≥ 3 months

- Adequate hematologic, hepatic, and renal function

Exclusion Criteria:

- Brain metastases that are progressing or have been documented to be stable for less
than 3 months, or for which systemic corticosteroids are required

- Investigational drug use within 28 days of the first dose of PLX4032

- Uncontrolled intercurrent illness

- Refractory nausea and vomiting, malabsorption, or significant bowel resection that
would preclude adequate absorption