Inclusion Criteria:

- Cancer confirmed by histology or cytology

- At least one measurable lesion

- Advanced disease refractory to standard therapy or for which no standard therapy
exists

- Life expectancy of at least 3 months

Exclusion Criteria:

- Known secondary neoplasia or central nervous system (CNS) metastases; acute or
chronic leukemia, lymphoma or multiple myeloma

- Body weight below 45 kg

- Female patients who are pregnant or breast feeding or adults of reproductive
potential not employing effective method of birth control

- Confirmed diagnosis of HIV

- Insulin dependent diabetes mellitus / abnormal glucose tolerance test (GTT) / latent
diabetes mellitus type I or II

- Chemotherapy or radiotherapy less than 4 weeks prior to entry

- Surgery less than 2 weeks prior to entry (or not recovered from effects of surgery)

- Participation in a clinical trial less than 30 days prior to entry in the study