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n-3 and Trans Fatty Acids and Major Cardiovascular Outcomes

65 Years
Not Enrolling
Cardiovascular Diseases, Heart Failure, Congestive, Atrial Fibrillation, Cerebrovascular Accident

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Trial Information

n-3 and Trans Fatty Acids and Major Cardiovascular Outcomes

CVD includes diseases that affect the heart and blood vessels, including congestive heart
failure (CHF), atrial fibrillation (AF), and stroke. CVD may be associated with low levels
of n-3 fatty acids and high levels of trans-fatty acids, but more research is needed to
determine the role of various fatty acids in the development of CVD. Results from prior
studies on this topic have not always been reliable because data from self-reported dietary
questionnaires on fatty acid intake have sometimes been inaccurate. A more effective way to
measure levels of fatty acids is to analyze blood samples. This study will use blood samples
of participants in the Cardiovascular Health Study, a study that examined CVD risk factors
in older adults, to determine the link between various fatty acids and the incidence of CHF,
AF, and stroke. The results from this study may help researchers identify the dietary
factors that influence the development of CVD in older adults.

This study will examine previously collected data from participants in the Cardiovascular
Health Study. There will be no study visits specifically for this study. Plasma samples
obtained from participants will be analyzed for the presence of n-3 fatty acids and
trans-fatty acids. The study will also determine the incidence of CHF, AF, and stroke and
the way in which fatty acids are related to hemodynamics, heart structure and function,
electrophysiology, insulin sensitivity, inflammation, endothelial function, and obesity.

Inclusion Criteria:

- Participated in the Cardiovascular Health Study

Type of Study:


Study Design:


Principal Investigator

Dariush Mozaffarian, MD, DrPH

Investigator Role:

Principal Investigator

Investigator Affiliation:

Harvard Medical School and Harvard School of Public Health


United States: Federal Government

Study ID:




Start Date:

January 1989

Completion Date:

June 2006

Related Keywords:

  • Cardiovascular Diseases
  • Heart Failure, Congestive
  • Atrial Fibrillation
  • Cerebrovascular Accident
  • Stroke
  • Atrial Fibrillation
  • Cardiovascular Diseases
  • Heart Failure
  • Cerebral Infarction
  • Stroke



Fred Hutchinson Cancer Research Center Seattle, Washington  98109
Harvard School of Public Health Boston, Massachusetts  02115
Channing Laboratory, Harvard Medical School Boston, Massachusetts  02115
Cardiovascular Health Research Unit, University of Washington Seattle, Washington  98101