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A Phase I Single-institution, Open-label, Dose-escalating, Clinical and Pharmacokinetic Study of PM02734 Administered Every 3 Weeks, Intravenously, Over 30 Minutes, to Subjects With Advanced Malignant Solid Tumors.


Phase 1
18 Years
N/A
Not Enrolling
Both
Solid Tumors

Thank you

Trial Information

A Phase I Single-institution, Open-label, Dose-escalating, Clinical and Pharmacokinetic Study of PM02734 Administered Every 3 Weeks, Intravenously, Over 30 Minutes, to Subjects With Advanced Malignant Solid Tumors.


Phase I single-institution, open-label, dose-escalating, clinical and pharmacokinetic study.
The purpose is to determine the safety, tolerability and to identify the dose limiting
toxicities(DLT) and recommended dose (RD) of PM02734 administered every 3 weeks,
intravenously, over 30 minutes to subjects with advanced malignant solid tumors. Secondary
objectives are to determine preliminary Pharmacokinetics of PM02734, to explore the
relationships between pharmacokinetics and pharmacodynamics. To evaluate the preliminary
pharmacokinetics/pharmacodynamics correlation and to evaluate the preliminary antitumor
activity of PM02734. The trial will be conducted in compliance with the protocol, GCP and
applicable regulatory requirements.


Inclusion Criteria:



1. Voluntary written informed consent of the subject obtained before any study-specific
procedure.

2. Histologically or cytologically confirmed malignant solid tumor.

3. Subjects with malignancies for which no standard therapy would reasonably be expected
to result in cure or palliation.

4. Age ≥ 18 years.

5. Subject with measurable or non-measurable disease using the RECIST criteria (only
subjects with measurable disease are allowed to enter the expanded cohort).

6. Recovery from any drug-related adverse event derived from previous treatment,
excluding alopecia and NCI-CTCAE grade 1 symptomatic peripheral neuropathy.

7. Laboratory values within 7 days prior to first infusion:

- Platelet count ≥ 100 x109/L , hemoglobin > 9 g/dL and absolute neutrophil
count (ANC) ≥ 1.5 x109/L.

- Alkaline phosphatase ≤ 2.5 x the upper limit of normality (ULN) (< 5 x ULN in
case of extensive bone metastases).

- Aspartate aminotransferase (AST): ≤ 2.5 x ULN (<5 x ULN in case of extensive
liver metastases).

- Alanine aminotransferase (ALT): ≤ 2.5 x ULN (<5 x ULN in case of extensive liver
metastases).

- Total bilirubin:1.5 ≤ ULN, unless due to Gilbert's syndrome.

- Creatinine: ≤ ULN, or measured creatinine clearance: ≥ 60 mL/min without
significant proteinuria (>250 mg/m2 /day)

- Albumin ≥ 2.5 g/dL.

- Partial thromboplastin time ≤ 1.1 x ULN

- INR ≤ 1.1

8. Performance status (ECOG) ≤ 2 .

9. Life expectancy ≥ 3 months.

10. Left ventricular ejection fraction (LVEF) within normal limits.

11. Women of childbearing potential must have a negative serum pregnancy test before
study entry. Both men and women must agree to use a medically acceptable method of
contraception throughout the treatment period and for 3 months after discontinuation
of treatment. Acceptable methods of contraception include complete abstinence, IUD,
oral contraceptive, subdermal implant and double barrier (condom with a contraceptive
sponge or contraceptive suppository).

Exclusion Criteria:

1. Prior therapy with PM02734.

2. Pregnant or lactating women.

3. Less than 4 weeks from radiation therapy (8 weeks in case of extensive prior
radiotherapy) or last dose of hormonal therapy, biological therapy or chemotherapy (6
weeks in case of nitrosourea, mitomycin C, or high-dose chemotherapy).

4. Evidence of progressive CNS metastases or any symptomatic brain or leptomeningeal
metastases.

5. Evidence of extensive liver metastases ( more than 5 hepatic nodules and some of them
greater than 5 cm in diameter)

6. Other relevant diseases or adverse clinical conditions:

- Increased cardiac risk: congestive heart failure or unstable angor pectoris or
arrhythmia requiring treatment or uncontrolled arterial hypertension or
myocardial infarction within 12 months before inclusion in the study.

- History of significant neurological or psychiatric disorders.

- Active infection.

- Significant non-neoplastic liver disease (e.g., cirrhosis, active chronic
hepatitis).

- Significant non-neoplastic renal disease.

- Immunocompromised subjects, including subjects known to be infected by human
immunodeficiency virus (HIV).

- Uncontrolled endocrine diseases (e.g. diabetes mellitus, hypothyroidism or
hyperthyroidism, adrenal disorder) (i.e. requiring relevant changes in
medication within the last month or hospital admission within the last 3
months).

- Any other major illness that, in the investigator's judgment, will substantially
increase the risk associated with the subject's participation in this study.

7. Limitation of the subject's ability to comply with the treatment or to follow-up at a
participating protocol. Subjects registered on this trial must be treated and
followed at a participating center.

8. Treatment with ongoing anti-coagulation.

9. Treatment with any investigational product in the 30 days period prior to the first
infusion.

10. Known hypersensitivity to any of the components of the drug product.

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

To determine the safety, tolerability, dose limiting toxicities (DLT) and recommended dose (RD) of PM02734

Outcome Time Frame:

Along the study

Safety Issue:

Yes

Principal Investigator

Mark Ratain, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Cancer Research Centerr, University of Chicago Hospital

Authority:

United States: Food and Drug Administration

Study ID:

PM2734-A-001-05

NCT ID:

NCT00404521

Start Date:

August 2005

Completion Date:

May 2011

Related Keywords:

  • Solid Tumors
  • Tumor
  • PM02734
  • PharmaMar
  • Neoplasms

Name

Location

Cancer Research Center. University of Chicago HospitalsChicago, Illinois  60637