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Physical Exercise to Improve Physical Performance and Health Related Quality of Life in Hematopoietic Stem Cell Transplantation Recipients


Phase 0
18 Years
70 Years
Not Enrolling
Both
Hematopoietic Stem Cell Transplantation

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Trial Information

Physical Exercise to Improve Physical Performance and Health Related Quality of Life in Hematopoietic Stem Cell Transplantation Recipients


Peripheral Stem Cell Transplantation is a frequently used therapy option to increase
survival in hematological and lymphatic malignancies. These malignancies and their treatment
are associated with numerous physical and psychological symptoms and severe side effects.
Physical exercise has been proposed as a promising strategy for the treatment of some of
these physical and psychological complaints, and various exercise interventions are
currently available after cancer treatment. To date, promising preliminary results
concerning exercise programs in PBSCT recipients were published with limited sample size
populations. Results of musculoskeletal outcomes in PBSCT recipients after cancer treatment
are lacking.


Inclusion Criteria:



- Status after high-dose chemotherapy following Hematopoietic Stem Cell Transplantation

- Willing to enter a physical exercise program

- Good understanding of the German language

- Written informed consent

Exclusion Criteria:

- Uncontrolled cardiovascular disease and myocardial infarction in the previous six
months

- Uncontrolled hypertension

- Uncontrolled thyroid disease

- Uncontrolled diabetes

- Diagnosis of depression before entering the study.

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Supportive Care

Outcome Measure:

Musculoskeletal performance

Outcome Time Frame:

Baseline -3 months - 6 months

Safety Issue:

No

Principal Investigator

Neil K Aaronson, PhD

Investigator Role:

Study Chair

Investigator Affiliation:

Division of Psychosocial Research & Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Authority:

Switzerland: Ethikkommission

Study ID:

EK-519

NCT ID:

NCT00402753

Start Date:

January 2005

Completion Date:

December 2009

Related Keywords:

  • Hematopoietic Stem Cell Transplantation
  • Cancer, Exercise, Health Related Quality of Life, PBSCT

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