Inclusion Criteria:

- Cytologically and/or histologically confirmed NSCLC Stage IIIb or IV

- No previous systemic chemotherapy for this cancer

- At least one uni-dimensionally measurable lesion meeting Response Evaluation Criteria
In Solid Tumors (RECIST) criteria

- Eastern Cooperative Oncology Group (ECOG) Performance status of 0 or 1 and adequate
organ function

- Prior radiation therapy allowed but limited to <25% of the patient's bone marrow

Exclusion Criteria:

- Serious concomitant systemic disorder or active infection

- Mild to moderate renal insufficiency, but unable to interrupt salicylates or other
nonsteroidal anti-inflammatory drugs

- Symptomatic central nervous system (CNS) metastases requiring concurrent
corticosteroid therapy

- Presence of clinically significant third-space fluid collections