Inclusion Criteria

Inclusion Criteria

- Patients must have histologically or cytologically confirmed diagnosis of cancer for
which treatment with single agent docetaxel would be an appropriate treatment option.

- At least 18 years of age.

- Patients may be currently receiving docetaxel using the schedule in the protocol, as
long as the treating investigator has reasonable expectation that the patient will
continue to receive docetaxel for 2 or more additional cycles. The current regimen
does not count towards the 2 regimens as long as the patient is not progressing on
therapy..

- Patients must have a life expectancy of more than 3 months.

- Patients must have a performance status of 0 to 2 according to the ECOG criteria.

- Patients must have normal organ and marrow function as defined in the protocol:
leukocytes >=4,000/microL, absolute neutrophil count >=1,500/microL, platelets
>=100,000/microL, HCT > 28%, total bilirubin < 1.5 x upper limit of normal, AST
(SGOT)/ALT (SGPT) <=2.5 X institutional upper limit of normal, creatinine <= 2.5
mg/dl

- Patients must have recovered from acute toxicity related to prior therapy, excluding
alopecia, including surgery or radiotherapy.

- Patients must be able to ingest oral medications.

- Female patients who are pregnant or lactating are ineligible. All females of
childbearing potential must have a negative serum pregnancy test within 72 hours of
treatment. Men and women of childbearing potential must agree to employ adequate
contraception to prevent pregnancy while on therapy and for four weeks after the
completion of treatment.

- Patients must have ability to understand and the willingness to sign a written
informed consent document.

Exclusion Criteria

- Patients may not be receiving any other investigational agents or devices.

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to perifosine (miltefosine or edelfosine).

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection and psychiatric illness/social situations that would limit compliance with
study requirements.

- HIV-positive patients receiving combination anti-retroviral therapy are excluded from
the study because of possible pharmacokinetic interactions with perifosine.

- Patients with a history of unstable or newly diagnosed angina pectoris, recent
myocardial infarction (within 6 months of enrollment) or New York Heart Assoc. class
II-IV congestive heart failure.

- Patients with a history of hypersensitivity reaction to products containing
Polysorbate 80 (Tween 80).