Inclusion Criteria:

- Patients with a histologically or cytologically confirmed diagnosis of renal or
hepatocellular tumor are eligible for this protocol. Patients with other solid tumor
types must have their cases reviewed by the medical monitor.

- The physician must believe that the patient's course and the growth rate of the tumor
are such that the patient would feel comfortable continuing treatment for 12 weeks
even if there is a transient period of modest tumor growth during the first weeks
following the initiation of perifosine and sorafenib treatment.

- Patients must have a life expectancy of more than 6 months.

- Patients may have received prior sorafenib or sunitinib malate.

- Patients may have measurable or evaluable disease.

- Patients should have a performance status of 0 to 1 according to the ECOG criteria.

- Patients must have adequate organ and marrow function, unless in the opinion of the
treating investigator, the abnormality is related to tumor and the medical monitor
agrees the abnormality is unlikely to affect the safety of perifosine use.

- Patients must have recovered from acute toxicity related to prior therapy including
surgery or radiotherapy, excluding alopecia.

- Patients with breast cancer or prostate cancer who discontinue endocrine therapy
prior to entry onto this study must wait for a minimum of 1 month and then be
reassessed for a withdrawal response prior to starting perifosine. However, it is
not a requirement that endocrine therapies be discontinued.

- Patients must be able to ingest oral medications or to obtain them through a
gastrostomy tube.

- Patients must be at least 18 years of age.

- Patients must have ability to understand and the willingness to sign a written
informed consent document.

Exclusion Criteria:

- Rapidly progressing disease, as defined by progression within 12 weeks of initiation
of the previous regimen (see Section 8.2.8 below)

- Patients who have had more than three prior systemic therapies, including biologics,
are excluded unless prior approval is obtained from the medical monitor.

- Patients receiving any other investigational agents or devices

- Patients initiating treatment for their cancer within the last two months who will be
continued concomitantly with perifosine

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to perifosine (miltefosine or edelfosine)

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection and psychiatric illness/social situations that would limit compliance with
study requirements

- HIV-positive patients receiving combination anti-retroviral therapy are excluded from
the study because of possible pharmacokinetic interactions with perifosine.

- Patients with a history of unstable or newly diagnosed angina pectoris, recent
myocardial infarction (within 6 months of enrollment), or New York Heart Association
class II-IV congestive heart failure

- Female patients who are pregnant or lactating are ineligible.