Patient Adherence to Prescribed Therapy in Ulcerative Colitis: an Investigation of Barriers & Methods of Improvement.
Poor adherence to treatment is well recognised and significantly contributes to treatment
failures. In ulcerative colitis it may be associated with an increased risk of colorectal
cancer. Estimates for non-adherence range from 15% to 93% with an average of around a third
of patients failing to adhere to their recommended therapeutic regimen.
The study aims to evaluate a wide-ranging approach to reducing poor adherence, which is
based on factors associated with non-adherence and involves the patient in choosing
The effectiveness of the overall intervention will be assessed through a randomised
controlled trial comparing intervention against standard care.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Levels of patient adherence to therapy will be assessed in two ways:
John F Mayberry, DScMD
University Hospitals, Leicester
United Kingdom: Research Ethics Committee