Inclusion Criteria:

- PCO - ESHRE/ASRM criteria:oligomenorrhea (<8 spontaneus menses per year) and
hyperandrogenism(hirsutism or acne) or hyperandrogenemia(testosterone > 70 ng/ml)
normal prolactin, TSH, 17-OH progesterone no evidence of androgen producing
malignancy, Cushing's syndrome or acromegaly age 18-40 reliable use of birth control
pill for at least 3 months and no plans of pregnancy

Exclusion Criteria:

- elevated creatinine kinase above 2 times upper limit of normal or liver enzymes
(transaminase) above 2 times of upper limit of normal use of any following
medications: cyclosporine, fibrates niacin,antifungal agents, macrolide antibiotics
use of oral contraceptives and other steroid hormones 3 months prior to the study