Study of Positron Emission Tomography/CT Scan for Response Evaluation After Radiofrequency Ablation in Patients With Lung Metastases
- Determine the accuracy of positron emission tomography (PET) and CT scan in measuring
response at 3 months after radiofrequency ablation (RFA) in patients with lung
- Determine the agreement between observers analyzing PET/CT scan results.
- Determine the outcome of these patients.
- Determine the false-positive rate and false-negative rate of PET/CT scan at 1 and 3
months in these patients.
- Determine the optimal time for obtaining a negative PET scan.
- Determine the sensitivity, specificity, positive predictive value, and negative
predictive value of PET/CT scan at 1 and 3 months.
- Determine the morbidity associated with RFA.
- Determine the disease-free survival after RFA and the factors predicting recurrent
disease in these patients.
OUTLINE: This is a multicenter study.
Patients undergo positron emission tomography (PET) and CT scan at baseline. Patients then
undergo radiofrequency ablation (RFA) for lung metastases. PET/CT scan is repeated at 1
week, 1 month, and 3 months after RFA.
After completion of RFA, patients are followed by clinical examination and conventional
scanning at 6, 9, and 12 months.
PROJECTED ACCRUAL: A total of 80 patients will be accrued for this study.
Masking: Open Label, Primary Purpose: Diagnostic
Accuracy of positron emission tomography (PET) and CT scan in measuring response at 3 months after radiofrequency ablation (RFA)
Francoise Bonichon, MD
United States: Federal Government