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A Clinical Trial to Determine the Efficacy of Five Years of Letrozole Compared to Placebo in Patients Completing Five Years of Hormonal Therapy Consisting of an Aromatase Inhibitor (AI) or Tamoxifen Followed by an AI in Prolonging Disease-Free Survival in Postmenopausal Women With Hormone Receptor Positive Breast Cancer

Phase 3
18 Years
Open (Enrolling)
Breast Cancer

Thank you

Trial Information

A Clinical Trial to Determine the Efficacy of Five Years of Letrozole Compared to Placebo in Patients Completing Five Years of Hormonal Therapy Consisting of an Aromatase Inhibitor (AI) or Tamoxifen Followed by an AI in Prolonging Disease-Free Survival in Postmenopausal Women With Hormone Receptor Positive Breast Cancer



- Determine whether or not prolonged adjuvant hormonal therapy comprising letrozole vs
placebo will improve disease-free survival of postmenopausal women with estrogen
receptor-positive and/or progesterone receptor-positive breast cancer who have
completed 5 years of hormonal therapy with 5 years of an aromatase inhibitor (AI) or 5
years of a combination of up to 3 years of tamoxifen citrate followed by an AI.

- Compare the disease-free survival of patients treated with these regimens.


- Compare overall survival of patients treated with these regimens.

- Compare breast cancer-free interval of patients treated with these regimens.

- Compare distant recurrence in patients treated with these regimens.

- Compare the incidence of osteoporotic-related fractures (e.g., Colles', hip, and spine)
in these patients treated with these regimens.

- Compare the incidence of arterial thrombotic events in patients treated with these

OUTLINE: This is a double-blind, multicenter, placebo-controlled, randomized study. Patients
are stratified according to pathologic nodal status (negative vs positive), adjuvant
tamoxifen citrate therapy (yes vs no), and lowest bone mineral density T score for
lumbosacral spine, total hip, or femoral neck (> -2.0 vs ≤ -2.0 standard deviation).
Patients are randomized to 1 of 2 treatment arms.

- Arm I: Patients receive oral letrozole once daily.

- Arm II: Patients receive oral placebo once daily. In both arms, treatment continues for
up to 5 years in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed annually.

PROJECTED ACCRUAL: A total of 3,840 patients will be accrued for this study.

Inclusion Criteria


- Histologically confirmed invasive carcinoma of the breast by core needle or final
pathological evaluation of the surgical specimen

- Clinical stage I, II, or IIIA primary tumor for patients who received
neoadjuvant chemotherapy

- Primary tumor t1-3 on pathologic evaluation and ipsilateral nodes pN0, pN1
(pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b for patients who received
adjuvant chemotherapy

- Received adjuvant hormonal therapy after breast cancer diagnosis for a duration of
57-63 months from the first dose (regardless of the number of missed doses) with 1 of
the following:

- Aromatase inhibitor* (AI)

- Combination of up to 3 years of tamoxifen citrate followed by an AI for a total
of 5 years

- No tamoxifen citrate during years 4 and 5 of 5-year adjuvant hormonal
therapy NOTE: *Adjuvant AI therapy must be discontinued at the time of

- Must have completed adjuvant hormonal therapy within the past 6 months

- Must have undergone a bilateral mammogram within the past year (unilateral if patient
had a mastectomy)

- Mammogram not required if patient has a prophylactic contralateral mastectomy

- Must have undergone a bone mineral density test within the past year

- Must have undergone a lumpectomy with axillary nodal staging followed by breast
radiotherapy OR a total mastectomy with axillary nodal staging

- Nodal staging with sentinel node biopsy alone is allowed provided sentinel nodes
were negative on H&E staining

- No evidence of recurrent breast cancer by history and physical within the past 3

- No diagnosis of bilateral breast cancer, including ductal carcinoma in situ
(synchronous or metachronous)

- Estrogen receptor (ER)-positive and/or progesterone receptor-positive tumor

- Patients with a tumor considered to be borderline hormone receptor-positive that
was treated with tamoxifen citrate and/or AI are allowed


- Female

- Postmenopausal as defined by any of the following criteria:

- Age ≥ 56 years with no spontaneous menses for ≥ 12 months prior to study entry

- Age ≤ 55 years with no spontaneous menses for ≥ 12 months prior to study entry
(e.g., spontaneous or secondary to hysterectomy) AND a documented estradiol
level in the postmenopausal range

- Prior documented bilateral oophorectomy

- ECOG performance status 0 or 1

- Cholesterol ≤ grade 1 (with or without cholesterol-lowering therapy) meeting 1 of the
following criteria:

- Criteria must be met within the past year if patient has any of the following:

- History of hypercholesterolemia controlled with cholesterol-lowering
therapy and/or therapeutic lifestyle changes

- History of ≥ 1 of the following risk factors for cardiovascular events:

- Diabetes

- Hypertension

- Obesity

- Tobacco use

- Hypertriglyceridemia

- Documented coronary artery disease

- Family history of premature coronary heart disease

- Criteria must be met within the past 2 years for all other patients

- Not pregnant or nursing

- No history of nontraumatic osteoporotic fracture of the wrist, hip, or spine

- No other malignancies unless disease-free for ≥ 5 years and, in the opinion of the
investigator, at low risk for recurrence

- No other prior malignancy within the past 5 years except for the following:

- Carcinoma in situ of the cervix

- Colon carcinoma in situ

- Melanoma in situ

- Basal cell or squamous cell carcinoma of the skin


- See Disease Characteristics

- No other investigational agent within the past 30 days

- No other concurrent anticancer therapy

- No concurrent participation in any other hormonal therapy or placebo-controlled
supportive therapy clinical trial

- No other concurrent hormonal therapy, including any of the following:

- Hormonal agent for management of osteoporosis (e.g., raloxifene)

- Selective estrogen receptor modulators (e.g., raloxifene)

- Sex hormonal therapy (e.g., estrogen- or progesterone-replacement therapy,
including low-dose estrogen in the form of vaginal cream) or oral contraceptives

- Luteinizing hormone-releasing hormone agonists/antagonists (e.g., goserelin)

- Estradiol acetate

- Conjugated estrogen ring or estradiol hemihydrate vaginal tab allowed

- Other aromatase inhibitors

- Concurrent bisphosphonates allowed provided dose is as recommended for bone
protection, not anticancer therapy

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Outcome Measure:

Disease-free survival

Outcome Time Frame:

Time from randomization to local recurrence following mastectomy or lumpectomy (IBTR), regional recurrence, distant recurrence, second primary cancer or death from any cause prior to recurrence or second primary cancer.

Safety Issue:


Principal Investigator

Norman Wolmark, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

NSABP Foundation, Inc.


United States: Food and Drug Administration

Study ID:




Start Date:

August 2006

Completion Date:

October 2018

Related Keywords:

  • Breast Cancer
  • stage I breast cancer
  • stage II breast cancer
  • stage IIIA breast cancer
  • Breast Neoplasms



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McDonough District Hospital Macomb, Illinois  61455
Edward Hospital Cancer Center Naperville, Illinois  60540
Hematology Oncology Consultants - Naperville Naperville, Illinois  60540
BroMenn Regional Medical Center Normal, Illinois  61761
Community Cancer Center Normal, Illinois  61761
Community Hospital of Ottawa Ottawa, Illinois  61350
Oncology Hematology Associates of Central Illinois, PC - Ottawa Ottawa, Illinois  61350
Cancer Treatment Center at Pekin Hospital Pekin, Illinois  61554
Oncology Hematology Associates of Central Illinois, PC - Peoria Peoria, Illinois  61615
OSF St. Francis Medical Center Peoria, Illinois  61637
Proctor Hospital Peoria, Illinois  61614
Illinois Valley Community Hospital Peru, Illinois  61354
Perry Memorial Hospital Princeton, Illinois  61356
St. Margaret's Hospital Spring Valley, Illinois  61362
St. Francis Hospital and Health Centers - Beech Grove Campus Beech Grove, Indiana  46107
Center for Cancer Therapy at LaPorte Hospital and Health Services La Porte, Indiana  46350
Bettendorf, Iowa  52722
St. Luke's Hospital Cedar Rapids, Iowa  52402
Mercy Regional Cancer Center at Mercy Medical Center Cedar Rapids, Iowa  52403
Genesis Medical Center - West Campus Davenport, Iowa  52804
Genesis Regional Cancer Center at Genesis Medical Center Davenport, Iowa  52803
John Stoddard Cancer Center at Iowa Lutheran Hospital Des Moines, Iowa  50316-2301
Mercy Capitol Hospital Des Moines, Iowa  50307
Medical Oncology and Hematology Associates at Mercy Cancer Center Des Moines, Iowa  50314
Mercy Cancer Center at Mercy Medical Center - Des Moines Des Moines, Iowa  50314
Cancer Center of Kansas, PA - Dodge City Dodge City, Kansas  67801
Pennington Cancer Center at Baton Rouge General Baton Rouge, Louisiana  70806
Mary Bird Perkins Cancer Center - Baton Rouge Baton Rouge, Louisiana  70809
Terrebonne General Medical Center Houma, Louisiana  70360
Medical Center of Louisiana - New Orleans New Orleans, Louisiana  70112
Sturdy Memorial Hospital Attleboro, Massachusetts  02703
Hickman Cancer Center at Bixby Medical Center Adrian, Michigan  49221
Bay Regional Medical Center Bay City, Michigan  48708
Mecosta County Medical Center Big Rapids, Michigan  49307
Upper Michigan Cancer Center at Marquette General Hospital Marquette, Michigan  49855
Community Cancer Center of Monroe Monroe, Michigan  48162
Providence Cancer Institute at Providence Hospital - Southfield Campus Southfield, Michigan  48075
Saint Francis Medical Center Cape Girardeau, Missouri  63701
Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center Grand Island, Nebraska  68803
Immanuel Medical Center Omaha, Nebraska  68122
Creighton University Medical Center Omaha, Nebraska  68131-2197
Booker Cancer Center at Riverview Medical Center Red Bank, New Jersey  07701
Cancer Institute of New Jersey at Cooper - Voorhees Voorhees, New Jersey  08043
Adirondack Cancer Care - Glens Falls Glens Falls, New York  12801
Charles R. Wood Cancer Center at Glens Falls Hospital Glens Falls, New York  12801
Iredell Memorial Hospital Statesville, North Carolina  28677
Forsyth Regional Cancer Center at Forsyth Medical Center Winston-Salem, North Carolina  27103
Bismarck Cancer Center Bismarck, North Dakota  58501
Wood County Oncology Center Bowling Green, Ohio  43402
Samaritan North Cancer Care Center Dayton, Ohio  45415
Grandview Hospital Dayton, Ohio  45405
David L. Rike Cancer Center at Miami Valley Hospital Dayton, Ohio  45409
Good Samaritan Hospital Dayton, Ohio  45406
Blanchard Valley Medical Associates Findlay, Ohio  45840
Charles F. Kettering Memorial Hospital Kettering, Ohio  45429
Lima Memorial Hospital Lima, Ohio  45804
St. Luke's Hospital Maumee, Ohio  43537
Northwest Ohio Oncology Center Maumee, Ohio  43537
Middletown Regional Hospital Middletown, Ohio  45044
Toledo Clinic - Oregon Oregon, Ohio  43616
St. Charles Mercy Hospital Oregon, Ohio  43616
North Coast Cancer Care, Incorporated Sandusky, Ohio  44870
Mercy Medical Center Springfield, Ohio  45504
Mercy Hospital of Tiffin Tiffin, Ohio  44883
Toledo Clinic, Incorporated - Main Clinic Toledo, Ohio  43623
UVMC Cancer Care Center at Upper Valley Medical Center Troy, Ohio  45373-1300
Fulton County Health Center Wauseon, Ohio  43567
Cleveland Clinic - Wooster Wooster, Ohio  44691
Ruth G. McMillan Cancer Center at Greene Memorial Hospital Xenia, Ohio  45385
Legacy Mount Hood Medical Center Gresham, Oregon  97030
Providence Milwaukie Hospital Milwaukie, Oregon  97222
Kaiser Permanente Health Care - Portland Portland, Oregon  97232
Providence Cancer Center at Providence Portland Medical Center Portland, Oregon  97213-2967
Providence St. Vincent Medical Center Portland, Oregon  97225
Legacy Meridian Park Hospital Tualatin, Oregon  97062
Bryn Mawr Hospital Bryn Mawr, Pennsylvania  19010
St. Mary Regional Cancer Center Langhorne, Pennsylvania  19047
Lankenau Cancer Center at Lankenau Hospital Wynnewood, Pennsylvania  19096
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center Kingsport, Tennessee  37662
UMC Southwest Cancer and Research Center Lubbock, Texas  79415-3364
Dixie Regional Medical Center - East Campus Saint George, Utah  84770
Mountainview Medical Berlin, Vermont  05602
Southwest Washington Medical Center Cancer Center Vancouver, Washington  98668
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima, Washington  98902
Washington Hematology-Oncology Specialists Yakima, Washington  98902
Holy Family Memorial Medical Center Cancer Care Center Manitowoc, Wisconsin  54221-1450
Welch Cancer Center at Sheridan Memorial Hospital Sheridan, Wyoming  82801
San Francisco General Hospital Medical Center San Francisco, California  94110
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital Fairbanks, Alaska  99701
St. Anthony Central Hospital Denver, Colorado  80204-1335
Denver Health Medical Center Denver, Colorado  80204-4507
Exempla Lutheran Medical Center Wheat Ridge, Colorado  80033
St. Francis Hospital Federal Way, Washington  98003
Cascade Cancer Center at Evergreen Hospital Medical Center Kirkland, Washington  98034-3013
St. Clare Hospital Lakewood, Washington  98499-0998
Providence St. Peter Hospital Regional Cancer Center Olympia, Washington  98506
Good Samaritan Cancer Center Puyallup, Washington  98371
Valley Medical Center Renton, Washington  98055
Allenmore Hospital Tacoma, Washington  98411-0414
Bristol Hospital Bristol, Connecticut  06011-0977
Lancaster General Hospital Lancaster, Pennsylvania  17604-3555
Highland General Hospital Oakland, California  94602
Middlesex Hospital Cancer Center Middletown, Connecticut  06457
Northeast Georgia Medical Center Gainesville, Georgia  30501
Creticos Cancer Center at Advocate Illinois Masonic Medical Center Chicago, Illinois  60657
Great Lakes Cancer Institute at McLaren Regional Medical Center Flint, Michigan  48532
Regional Cancer Center at Singing River Hospital Pascagoula, Mississippi  39581
Saint Luke's Hospital Chesterfield, Missouri  63017
Missouri Baptist Cancer Center St. Louis, Missouri  63131
Cancer Resource Center - Lincoln Lincoln, Nebraska  68510
Randolph Hospital Asheboro, North Carolina  27203
Moses Cone Regional Cancer Center at Wesley Long Community Hospital Greensboro, North Carolina  27401
Annie Penn Cancer Center Reidsville, North Carolina  27320
Altru Cancer Center at Altru Hospital Grand Forks, North Dakota  58201
Cancer Treatment Center Wooster, Ohio  44691
Allegheny Cancer Center at Allegheny General Hospital Pittsburgh, Pennsylvania  15212
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital Pittsburgh, Pennsylvania  15224-1791
St. Joseph Medical Center Reading, Pennsylvania  19604
Midelfort Clinic - Luther Eau Claire, Wisconsin  54702
Alta Bates Summit Comprehensive Cancer Center Berkeley, California  94704
Stanford Cancer Center Stanford, California  94305-5824
Praxair Cancer Center at Danbury Hospital Danbury, Connecticut  06810
Eastern Connecticut Hematology and Oncology Associates Norwich, Connecticut  06360
Carl and Dorothy Bennett Cancer Center at Stamford Hospital Stamford, Connecticut  06904
Tunnell Cancer Center at Beebe Medical Center Lewes, Delaware  19958
Herbert D. Kerman Regional Oncology Center - Daytona Beach Daytona Beach, Florida  32114
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital Fort Lauderdale, Florida  33308
Florida Cancer Specialists - Sarasota Downtown Sarasota, Florida  34236
John B. Amos Cancer Center Columbus, Georgia  31904
Harbin Clinic Cancer Center - Medical Oncology Rome, Georgia  30165
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler Savannah, Georgia  31405
Evanston Hospital Evanston, Illinois  60201-1781
Reid Hospital & Health Care Services Richmond, Indiana  47374
McFarland Clinic, PC Ames, Iowa  50010
Covenant Cancer Treatment Center Waterloo, Iowa  50702
Hospital District Sixth of Harper County Anthony, Kansas  67003
Cancer Center of Kansas, PA - Chanute Chanute, Kansas  66720
Cancer Center of Kansas, PA - El Dorado El Dorado, Kansas  67042
Cancer Center of Kansas - Fort Scott Fort Scott, Kansas  66701
Cancer Center of Kansas-Independence Independence, Kansas  67301
Cancer Center of Kansas, PA - Kingman Kingman, Kansas  67068
Lawrence Memorial Hospital Lawrence, Kansas  66044
Cancer Center of Kansas, PA - Newton Newton, Kansas  67114
Cancer Center of Kansas, PA - Parsons Parsons, Kansas  67357
Cancer Center of Kansas, PA - Pratt Pratt, Kansas  67124
Cancer Center of Kansas, PA - Salina Salina, Kansas  67401
Cotton-O'Neil Cancer Center Topeka, Kansas  66606
Cancer Center of Kansas, PA - Wellington Wellington, Kansas  67152
Cancer Center of Kansas, PA - Wichita Wichita, Kansas  67214
Associates in Womens Health, PA - North Review Wichita, Kansas  67208
Cancer Center of Kansas, PA - Medical Arts Tower Wichita, Kansas  67208
Cancer Center of Kansas, PA - Winfield Winfield, Kansas  67156
Drs. Carrol, Sheth, Raghavan Louisville, Kentucky  40215
Ochsner Health Center - Bluebonnet Baton Rouge, Louisiana  70809
Greater Baltimore Medical Center Cancer Center Baltimore, Maryland  21204
Union Hospital Cancer Program at Union Hospital Elkton MD, Maryland  21921
Foote Memorial Hospital Jackson, Michigan  49201
Haematology-Oncology Associates of Ohio and Michigan, PC Lambertville, Michigan  48144
St. Mary Mercy Hospital Livonia, Michigan  48154
Mercy Memorial Hospital - Monroe Monroe, Michigan  48162
St. Joseph Mercy Oakland Pontiac, Michigan  48341-2985
Mercy Regional Cancer Center at Mercy Hospital Port Huron, Michigan  48060
Seton Cancer Institute at Saint Mary's - Saginaw Saginaw, Michigan  48601
St. Luke's Hospital Cancer Care Center Duluth, Minnesota  55805
Arch Medical Services, Incorporated at Center for Cancer Care and Research Saint Louis, Missouri  63141
Billings Clinic - Downtown Billings, Montana  59107-7000
Bozeman Deaconess Cancer Center Bozeman, Montana  59715
St. James Healthcare Cancer Care Butte, Montana  59701
Sletten Cancer Institute at Benefis Healthcare Great Falls, Montana  59405
Northern Montana Hospital Havre, Montana  59501
Kalispell Medical Oncology at KRMC Kalispell, Montana  59901
Alegant Health Cancer Center at Bergan Mercy Medical Center Omaha, Nebraska  68124
Frederick R. and Betty M. Smith Cancer Treatment Center Sparta, New Jersey  07871
Monter Cancer Center of the North Shore-LIJ Health System Lake Success, New York  11042
Leo W. Jenkins Cancer Center at ECU Medical School Greenville, North Carolina  27834
Summa Center for Cancer Care at Akron City Hospital Akron, Ohio  44309-2090
Barberton Citizens Hospital Barberton, Ohio  44203
Mary Rutan Hospital Bellefontaine, Ohio  43311
Christ Hospital Cancer Center Cincinnati, Ohio  45219
North Coast Cancer Care - Clyde Clyde, Ohio  43410
Grant Medical Center Cancer Care Columbus, Ohio  43215
Hematology Oncology Center Elyria, Ohio  44035
Wayne Hospital Greenville, Ohio  45331
Flower Hospital Cancer Center Sylvania, Ohio  43560
St. Anne Mercy Hospital Toledo, Ohio  43623
Mount Carmel St. Ann's Cancer Center Westerville, Ohio  43081
Clinton Memorial Hospital Wilmington, Ohio  45177
Cleo Craig Cancer Research Clinic Lawton, Oklahoma  73505
Legacy Good Samaritan Hospital & Comprehensive Cancer Center Portland, Oregon  97210
Northwest Cancer Specialists at Rose Quarter Cancer Center Portland, Oregon  97227
Salem Hospital Regional Cancer Care Services Salem, Oregon  97309-5014
St. Luke's Cancer Network at St. Luke's Hospital Bethlehem, Pennsylvania  18015
Geisinger Hazleton Cancer Center Hazleton, Pennsylvania  18201
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center Reading, Pennsylvania  19612-6052
Hematology and Oncology Associates of Northeastern Pennsylvania Scranton, Pennsylvania  18510
York Cancer Center at Apple Hill Medical Center York, Pennsylvania  17405
Sandra L. Maxwell Cancer Center Cedar City, Utah  84720
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center Murray, Utah  84157
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center Ogden, Utah  84403
Fredericksburg Oncology, Incorporated Fredericksburg, Virginia  22401
Southwest Virginia Regional Cancer Center at Wellmonth Health Norton, Virginia  24273
St. Joseph Cancer Center Bellingham, Washington  98225
Providence Centralia Hospital Centralia, Washington  98531-9027
Franciscan Cancer Center at St. Joseph Medical Center Tacoma, Washington  98405-3004
Wenatchee Valley Medical Center Wenatchee, Washington  98801-2028
Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital Parkersburg, West Virginia  26102
Schiffler Cancer Center at Wheeling Hospital Wheeling, West Virginia  26003
Marshfield Clinic - Chippewa Center Chippewa Falls, Wisconsin  54729
Marshfield Clinic Cancer Care at Regional Cancer Center Eau Claire, Wisconsin  54701
Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn Elkhorn, Wisconsin  53121
Oncology Alliance, SC - Milwaukee - East Glendale, Wisconsin  53212-1038
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center Green Bay, Wisconsin  54311
Vince Lombardi Cancer Clinic - Marinette Marinette, Wisconsin  54143
Saint Joseph's Hospital Marshfield, Wisconsin  54449
Medical Consultants, Limited Milwaukee, Wisconsin  53215
Marshfield Clinic - Lakeland Center Minocqua, Wisconsin  54548
Ministry Medical Group at Saint Mary's Hospital Rhinelander, Wisconsin  54501
Vince Lombardi Cancer Clinic - Sheboygan Sheboygan, Wisconsin  53081
Saint Michael's Hospital Cancer Center Stevens Point, Wisconsin  54481
Vince Lombardi Cancer Clinic - Two Rivers Two Rivers, Wisconsin  54241
Marshfield Clinic - Wausau Center Wausau, Wisconsin  54401
Marshfield Clinic - Weston Center Weston, Wisconsin  54476
Diagnostic and Treatment Center Weston, Wisconsin  54476
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids, Wisconsin  54494
Cancer Resource Center at King's Daughters Medical Center Ashland, Kentucky  41101
Mid Dakota Clinic, PC Bismarck, North Dakota  58501
Regional Cancer Center at Memorial Medical Center Springfield, Illinois  62781-0001
Saint Louis University Cancer Center Saint Louis, Missouri  63110
Auburn Regional Center for Cancer Care Auburn, Washington  98002
Morton Plant Hospital Clearwater, Florida  33756
Community Hospital Munster, Indiana  46321
Consultants in Blood Disorders and Cancer Louisville, Kentucky  40207
Sacred Heart Hospital Allentown, Pennsylvania  18102
Aurora Sinai Medical Center Milwaukee, Wisconsin  53201-0342
St. Joseph Hospital Regional Cancer Center - Orange Orange, California  92868-3849
Phoebe Cancer Center at Phoebe Putney Memorial Hospital Albany, Georgia  31702
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center Pomona, California  91767
Queen's Cancer Institute at Queen's Medical Center Honolulu, Hawaii  96813
Good Samaritan Cancer Center at Good Samaritan Hospital Kearney, Nebraska  68848-1990
Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center Englewood, New Jersey  07631
Pardee Memorial Hospital Hendersonville, North Carolina  28791
Rutherford Hospital Rutherfordton, North Carolina  28139
Three Rivers Community Hospital Grants Pass, Oregon  97527
Dubs Cancer Center at Rogue Valley Medical Center Medford, Oregon  97504
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center Spartanburg, South Carolina  29303
Regional Cancer Center at Oconomowoc Memorial Hospital Oconomowoc, Wisconsin  53066
Kinston Medical Specialists Kinston, North Carolina  28501
Miriam Hospital Providence, Rhode Island  02906
MedCentral - Mansfield Hospital Mansfield, Ohio  44903
Glendale Memorial Hospital Comprehensive Cancer Center Glendale, California  91204
North Valley Breast Clinic Redding, California  96001
Resurrection Medical Center Chicago, Illinois  60631
Sherman Hospital Elgin, Illinois  60120-2198
Frederick Memorial Hospital Regional Cancer Therapy Center Frederick, Maryland  21701
Jordan Hospital Club Cancer Center Plymouth, Massachusetts  02360
Lapeer Regional Hospital Lapeer, Michigan  48446
St. John's Regional Medical Center Joplin, Missouri  64804
Freeman Cancer Institute at Freeman Health System Joplin, Missouri  64803-2644
McLeod Regional Medical Center Florence, South Carolina  29501
Presbyterian Hospital of Dallas Dallas, Texas  75231
Nalitt Cancer Institute at Staten Island University Hospital Staten Island, New York  10305
Providence Cancer Center Anchorage, Alaska  99508
La Grange Memorial Hospital La Grange, Illinois  60525
Cedar Valley Medical Specialists, PC - West Ridgeway Avenue Waterloo, Iowa  50702
Lacks Cancer Center at Saint Mary's Health Care Grand Rapids, Michigan  49503
Metro Health Hospital Grand Rapids, Michigan  49506
Great Falls, Montana  59405
Guardian Oncology and Center for Wellness Missoula, Montana  59804
Lakes Region General Hospital Laconia, New Hampshire  03246
St. Charles Medical Center - Bend Bend, Oregon  97701
Roper St. Francis Cancer Center at Roper Hospital Charleston, South Carolina  29401
Rockwood Clinic Cancer Treatment Center Spokane, Washington  99204-2967
University of Wisconcin Cancer Center at Aspirus Wausau Hospital Wausau, Wisconsin  54401
Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare Vineland, New Jersey  08360
Lipson Cancer and Blood Center at Rochester General Hospital Rochester, New York  14621
Oncology Hematology Associates of Northern Pennsylvania, PC at Hahne Regional Cancer Center Dubois, Pennsylvania  15801
Cancer Center at Phoenixville Hospital Phoenixville, Pennsylvania  19460
Center for Cancer Care at OSF Saint Anthony Medical Center Rockford, Illinois  61108
Louisville Oncology at Norton Cancer Institute - Louisville Louisville, Kentucky  40202
Scripps Cancer Center - San Diego San Diego, California  92121
Doctors Medical Center - San Pablo Campus San Pablo, California  94806
Galesburg Clinic, PC Galesburg, Illinois  61401
Boston University Cancer Research Center Boston, Massachusetts  02118
St. Vincent Healthcare Cancer Care Services Billings, Montana  59101
University of Tennessee Cancer Institute - Memphis Memphis, Tennessee  38104
Desert Regional Medical Center Comprehensive Cancer Center Palm Springs, California  92262
Center for Cancer Care and Research at Watson Clinic, LLP Lakeland, Florida  33805
Berkshire Hematology Oncology, PC Pittsfield, Massachusetts  01201
Midwest Hematology Oncology Group, Incorporated Saint Louis, Missouri  63109
Lynchburg Hematology-Oncology Clinic Lynchburg, Virginia  24501
Providence Cancer Center at Providence Hospital Mobile, Alabama  36608
East Bay Radiation Oncology Center Castro Valley, California  94546
Contra Costa Regional Medical Center Martinez, California  94553-3156
El Camino Hospital Cancer Center Mountain View, California  94040
Larry G Strieff MD Medical Corporation Oakland, California  94609
Tom K Lee, Incorporated Oakland, California  94609
Bay Area Breast Surgeons, Incorporated Oakland, California  94609
Valley Medical Oncology Consultants - Pleasanton Pleasanton, California  94588
Connecticut Oncology & Hematology - Torrington Torrington, Connecticut  06790
Kapiolani Medical Center at Pali Momi Aiea, Hawaii  96701
Kapiolani Medical Center for Women and Children Honolulu, Hawaii  96826
Straub Clinic and Hospital, Incorporated Honolulu, Hawaii  96813
Hawaii Medical Center - East Honolulu, Hawaii  96817
OnCare Hawaii, Incorporated - Kuakini Honolulu, Hawaii  96817
OnCare Hawaii, Incorporated - Lusitana Honolulu, Hawaii  96813
Maui Memorial Medical Center Wailuku, Hawaii  96793
Pacific Cancer Institute - Maui Wailuku, Hawaii  96793
Alexian Brothers Radiation Oncology Elk Grove Village, Illinois  60007
Elmhurst Memorial Hospital Elmhurst, Illinois  60126
Trinity Cancer Center at Trinity Medical Center - 7th Street Campus Moline, Illinois  61265
OSF Holy Family Medical Center Monmouth, Illinois  61462
Iowa Blood and Cancer Care Cedar Rapids, Iowa  52402
York Hospital's Oncology Treatment Center York, Maine  03909
Mercy General Health Partners Muskegon, Michigan  49443
Hattiesburg Clinic, PA at Forrest General Hattiesburg, Mississippi  39401
New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care Concord, New Hampshire  03301
Center for Cancer Care at Exeter Hospital Exeter, New Hampshire  03833
New Hampshire Oncology - Hematology, PA - Hooksett Hooksett, New Hampshire  03106
Valley Hospital - Ridgewood Ridgewood, New Jersey  07450
United States Air Force Medical Center - Wright-Patterson Wright-Patterson AFB, Ohio  45433-5529
Bay Area Hospital Coos Bay, Oregon  97420
Riddle Memorial Hospital Cancer Center Media, Pennsylvania  19063
Cancer Center of Paoli Memorial Hospital Paoli, Pennsylvania  19301-1792
CCOP - Main Line Health Wynnewood, Pennsylvania  19096
AnMed Cancer Center Anderson, South Carolina  29621
U.T. Medical Center Cancer Institute Knoxville, Tennessee  37920-6999
Dale and Frances Hughes Cancer Center at Pocono Medical Center East Stroudsburg, Pennsylvania  18301
Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center Upland, Pennsylvania  19013
Cancer Care Center, Incorporated Salem, Ohio  44460
St. Anthony's Cancer Center St. Louis, Missouri  63128
Medcenter One Hospital Cancer Care Center Bismarck, North Dakota  58501
St. Alexius Medical Center Cancer Center Bismarck, North Dakota  58502
University of Colorado Cancer Center at UC Health Sciences Center Aurora, Colorado  80045
Center for Cancer Care at Goshen General Hospital Goshen, Indiana  46526
Cleveland Clinic Florida - Weston Weston, Florida  33331
St. Mary's Regional Cancer Center at St. Mary's Medical Center Huntington, West Virginia  25702
Ocean Medical Center at Meridian Health Brick, New Jersey  08724
High Point Regional Hospital High Point, North Carolina  27261
Providence Cancer Center at PMCC Medford, Oregon  97504
Augusta Oncology Associates - Walton Way Augusta, Georgia  30901
Christus Schumpert Cancer Treatment Center Shreveport, Louisiana  71101
CaroMont Cancer Center at Gaston Memorial Hospital Gastonia, North Carolina  28053
Commonwealth Hematology-Oncology, PC - Worcester Worcester, Massachusetts  01605
Lovelace Medical Center - Downtown Albuquerque, New Mexico  87102
Callahan Cancer Center at Great Plains Regional Medical Center North Platte, Nebraska  69103
Hematology Oncology Associates, PC Albuquerque, New Mexico  87106
Regional Medical Center Anniston, Alabama  36202
Valley Medical Oncology Consultants - Castro Valley Castro Valley, California  94546
Valley Medical Oncology Fremont, California  94538
Cancer Care Associates Fresno, California  93720
Memorial Hospital Cancer Center - Colorado Springs Colorado Springs, Colorado  80909
Integrated Community Oncology Network - Orange Park Orange Park, Florida  32073
Provena St. Mary's Regional Cancer Center - Kankakee Kankakee, Illinois  60901
Heartland Oncology and Hematology Council Bluffs, Iowa  51503
Hudner Oncology Center at Saint Anne's Hospital - Fall River Fall River, Massachusetts  02721
Addison Gilbert Hospital Gloucester, Massachusetts  01930
NSMC Cancer Center - Peabody Peabody, Massachusetts  01960
Immanuel St. Joseph's Mankato, Minnesota  56002
Alamance Cancer Center at Alamance Regional Medical Center Burlington, North Carolina  27216
Marion L. Shepard Cancer Center at Beaufort County Hospital Washington, North Carolina  27889
Luther Midlelfort Hospital Eau Claire, Wisconsin  54702
Mercy Regional Cancer Center Janesville, Wisconsin  53547
Columbia Saint Mary's Hospital - Ozaukee Mequon, Wisconsin  53097
Columbia-Saint Mary's Cancer Care Center Milwaukee, Wisconsin  53211
Frankford Hospital Cancer Center - Torresdale Campus Philadelphia, Pennsylvania  19114
Cancer Care Center at John Muir Health - Concord Campus Concord, California  94524-4110
Georgia Cancer Center for Excellence at Grady Memorial Hospital Atlanta, Georgia  30303
Central Maine Comprehensive Cancer Center at Central Maine Medical Center Lewiston, Maine  04240
Shore Regional Cancer Center at Memorial Hospital - Easton Easton, Maryland  21601
Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus Boca Raton, Florida  33486
Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - West Boca Raton, Florida  33428
Mercy Medical Center Baltimore, Maryland  21202
CentraState Medical Center Freehold, New Jersey  07728
University Medical Center at Princeton Princeton, New Jersey  08540
Virginia K. Crosson Cancer Center at St. Jude Medical Center Fullerton, California  92835
Emory Crawford Long Hospital Atlanta, Georgia  30308
Mount Carmel Regional Cancer Center Pittsburg, Kansas  66762
St. Mary's Hospital Leonardtown, Maryland  20650
Caritas Holy Family Hospital Methuen, Massachusetts  01844
New York Oncology Hematology, PC at Albany Regional Cancer Care Albany, New York  12208
Amsterdam Community Cancer Program Amsterdam, New York  12010
Riverview Cancer Care Medical Associates, PC Rexford, New York  12148
Samaritan Hospital at Northeast Health Troy, New York  12180
Oncology Hematology Care, Incorporated - Blue Ash Cincinnati, Ohio  45242
St. Mary Regional Cancer Center at St. Mary Medical Center Walla Walla, Washington  99362
Hudson Valley Oncology Associates Poughkeepsie, New York  12601
St. Agnes Hospital Cancer Center Baltimore, Maryland  21229
Aurora Women's Pavilion of West Allis Memorial Hospital West Allis, Wisconsin  53227
New York Oncology Hematology, PC at Albany Medical Center Albany, New York  12208
New York Oncology Hematology, PC - Hudson Hudson, New York  12534
Norwalk Hospital Norwalk, Connecticut  06856
Community Regional Cancer Care at Community Hospital North Indianapolis, Indiana  46256
Community Regional Cancer Care at Community Hospital East Indianapolis, Indiana  46219
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh, Wisconsin  54904
Shaw Regional Cancer Center Edwards, Colorado  81632
Kootenai Cancer Center - Coeur d'Alene Coeur d'Alene, Idaho  83814
Central Dupage Cancer Center Warrenville, Illinois  60555
Clemens Regional Medical Center Mount Clemens, Michigan  48043
Cleveland Clinic Beachwood Family Health and Surgery Center Beachwood, Ohio  44122
Riverview UW Cancer Center at Riverview Hospital Wisconsin Rapids, Wisconsin  54494
Mercy Hospital Portland, Maine  04101
United Hospital Center Clarksburg, West Virginia  26301
North Broward Medical Center Dearfield Beach, Florida  33064-3596
Northeast Georgia Cancer Care, LLC - Medical Oncology Athens, Georgia  30607
St. Francis Regional Cancer Center Trenton, New Jersey  08629
Capital Health Regional Cancer Center Trenton, New Jersey  08618
Cancer Center of Poughkeepsie Poughkeepsie, New York  12601
Dyson Center for Cancer Care at Vassar Brothers Medical Center Poughkeepsie, New York  12601-3990
AtlantiCare Cancer Care Institute at AtlantiCare Regional Medical Center - Mainland Campus Pomona, New Jersey  08240
Portsmouth Regional Hospital Portsmouth, New Hampshire  03802
Southwest Regional Cancer Center - Central Austin, Texas  78705
Breastlink Medical Group, Incorporated at Long Beach Memorial Medical Center Long Beach, California  90806
Pacific Shores Medical Group - Long Beach Long Beach, California  90813
Drs Gurtler Brinz and Russo APMC-Metairie Oncologists Metairie, Louisiana  70006
Commonwealth Hematology-Oncology, PC - Concord Concord, Massachusetts  01742
Commonwealth Hematology Oncology PC - Dorchester Dorchester, Massachusetts  02124
Commonwealth Hematology-Oncology, PC - Lawrence Lawrence, Massachusetts  01842
Commonwealth Hematology Oncology PC - Leominster Leominster, Massachusetts  01453
Commonwealth Hematology-Oncology, PC - Quincy Quincy, Massachusetts  02169
Commonwealth Hematology-Oncology, PC - Stoneham Stoneham, Massachusetts  02180
Commonwealth Hematology-Oncology, PC - Weymouth Weymouth, Massachusetts  02190
New York Oncology Hematology, PC - Latham Latham, New York  12110
Texas Oncology, PA at Texas Oncology Cancer Center - Central Austin, Texas  78731
Texas Oncology, PA at Texas Cancer Center Round Rock Round Rock, Texas  78681
Overlake Cancer Center at Overlake Hospital Medical Center Bellevue, Washington  98004
Cancer Care Northwest - North Spokane, Washington  99218
New Mexico Cancer Center Albuquerque, New Mexico  87109
Seacoast Cancer Center at Wentworth - Douglass Hospital Dover, New Hampshire  03820
Saint Francis Hospital Cancer Center Poughkeepsie, New York  12601
Georgetown Memorial Hospital Georgetown, South Carolina  29440
Horizon Oncology Center Lafayette, Indiana  47905
Northern Westchester Hospital Mount Kisco, New York  10549
Waverly Hematology Oncology Cary, North Carolina  27518
Charles A. & Betty Bott Cancer Center at Holy Redeemer Hospital Meadowbrook, Pennsylvania  19046
Coney Island Hospital Brooklyn, New York  11235
Dickstein Cancer Treatment Center at White Plains Hospital Center White Plains, New York  10601
Harold Leever Regional Cancer Center Waterbury, Connecticut  06708
Simonds-Sinon Regional Cancer Center at HealthAlliance Hospital - Burbank Campus Fitchburg, Massachusetts  01420
Carolina Blood and Cancer Care Associates, PA Lancaster, South Carolina  29720
Carolina Blood and Cancer Care Rock Hill, South Carolina  29732
Lexington Medical Center West Columbia, South Carolina  29169
Texas Oncology, PA - Austin Northwest Austin, Texas  78759
Texas Oncology, PA - Austin North Austin, Texas  78759
Texas Oncology, PA - Cedar Park Cedar Park, Texas  78613
Texas Oncology, PA - Seton Williamson Round Rock, Texas  78665
Texas Oncology, PA - San Marcos San Marcos, Texas  78666