Intratumoral Cancer Chemotherapy Through a Flexible Bronchoscope as an Adjunct to Brachytherapy
Injections of cisplatin are given in conjunction with the brachytherapy procedure. If the
direct intratumoral injections result in a decrease in the endobronchial obstructed airways
and if the therapy is well tolerated, there will be immediate clinical benefit to this
minimally invasive method, the most obvious being an improved quality of life.
Approximately 2 mg cisplatin per cubic centimeter of tumor are injected into each tumor
through a flexible bronchoscope. A total of four to six injections are administered one
week apart. Response to therapy is assessed based on improvement in intraluminal
obstruction by tumor, as assessed by endobronchial observation.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
To affect a faster clearing of the obstruction as compared with initial evaluation, based on the percentage of lumen opened.
within 4 to 6 injections
Daniel Nader, DO
Cancer Treatment Centers of America at Southwestern Regional Medical Center, Inc.
United States: Institutional Review Board
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