Androgen Blockade Therapy and Thymic Function in Individuals Over 50 Years of Age With Adenocarcinoma of the Prostate: A Cross-Sectional Study
- Determine if inhibition of sex steroid action is associated with increased thymic size
in older patients who have undergone radical prostatectomy for localized adenocarcinoma
of the prostate.
- Determine if inhibition of sex steroid action is associated with an increase in the
absolute number or percentage of circulating "naive" phenotype T cells, and/or an
increase in the frequency of T-cell receptor excision circles in peripheral blood
OUTLINE: This is a nonrandomized, single-blind, cohort study. Patients are stratified
according to hormonal therapy after surgery (yes vs no).
Patients undergo CT scan of the thymus. Blood samples are analyzed by flow cytometry to
determine phenotype of T cells.
PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.
Observational Model: Cohort, Time Perspective: Prospective
Size of thymus as assessed by CT scan
approximately 4 hours during one session
Joseph M. McCune, MD, PhD
University of California, San Francisco
United States: Institutional Review Board
|UCSF Helen Diller Family Comprehensive Cancer Center||San Francisco, California 94115|