Inclusion Criteria:

Patients (> 18 years) with active cancer and at least one of the following indications for
thromboprophylaxis with LMWH:

- Immobilization

- History of VTE

- Acute inflammation

- Heart failure (NYHA class III or IV)

- Respiratory failure

Exclusion Criteria:

- Indication for LMWH or UFH at therapeutic dosages

- Treatment with antithrombotics (vitamin K antagonists, acetylsalicylic acid,
clopidogrel) for reasons other than prevention of VTE (e.g. atrial fibrillation,
myocardial infarction)

- Contraindication for the treatment with LMWH

- Major surgery within the last 4 weeks; minor surgery within the last week

- Thrombocytopenia (< 100.000/μl)

- Prolonged prothrombin time

- Prolonged activated partial thromboplastin time (aPTT)

- History of heparin-induced thrombocytopenia

- Bodyweight < 50 kg or > 100 kg

- Renal insufficiency (creatinine > 2 mg/dl)