Inclusion Criteria:

- age = 18 years old

- patients carrying a adenocarcinoma of the stomach or cardia histologically proven

- locally advanced tumour which may not be treated surgically or metastatic tumour

- the patients having a stenosante tumour responsible for a disphagy had to have a
tumoral ablation or a prosthesis or a probe of food,

- measurable lesions according to criteria RECIST (specify measurement by spiral
scanner of largest diameter of with less the one lesion of size higher than 1 cm) or
appraisable but nonmeasurable (lesions < 1 cm, ascite, pleural effusion...)

- general state WHO < 2

- absence of insufficiency cardiac or coronary symptomatic

- absence of previous chemotherapy other that auxiliary stopped since more than 6
months

- filled questionnaires QLQ C30 and STO-22

- PNN = 1500/mm3, haemoglobin ≥ 10g/dl, plates= 100 000/mm3

- creatinin ≤ 110 micromol/l

- bilirubin ≤ 35 micromol/l

Exclusion Criteria:

- disphagy or intestinal obstruction incompatible with a treatment per os or by a probe
of food

- pregnant or nursing woman

- previous of cardiac toxicity to the 5FU or to the anthracyclines

- radiotherapy less than 3 weeks before inclusion, whatever the site

- other evolutionary cancer threatening the short-term life

- metastasis cerebral or méningée known (without obligation to seek it)

- impossibility of regular follow-up for psychological, social, family or geographical
reasons